Catálogo de publicaciones - revistas

<jats:title>Molecular “go” signals reveal their secrets</jats:title> <jats:p> Chemokines are proteins that direct how cells move within the body. For instance, chemokines help immune cells locate invading pathogens and ensure that cells position themselves correctly within a developing organ. Cells detect chemokines through G protein–coupled receptors on their surface; however, the molecular details of how these proteins interact remain unclear (see the Perspective by Standfuss). Qin <jats:italic>et al.</jats:italic> solved the crystal structure of the chemokine receptor CXCR4 bound to the viral chemokine vMIP-II. Burg <jats:italic>et al.</jats:italic> solved the crystal structure of a viral chemokine receptor bound to the chemokine domain of CX3CL1. Given the role of chemokines in a number of diseases, these results may help in future drug design. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1117" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1261064">1117</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1113" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa5026">1113</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1071" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa7998">1071</jats:related-article> </jats:p>

<jats:title>Finding four for the light of one</jats:title> <jats:p> Seeing double may cause concern for some, but seeing quadruple? It's just what astronomers have been hoping for. Kelly <jats:italic>et al.</jats:italic> have now detected four images of the same distant supernova with the sharp eye of a space telescope. The supernova shines brightly from the arm of a spiral galaxy that lies far beyond another galaxy between it and us. This intervening galaxy is massive enough to bend the light from the supernova and its host galaxy into multiple images. This behavior relies on the curvature of spacetime and will provide insight into the luminous and dark matter in the lensing galaxy. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1123" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa3350">1123</jats:related-article> </jats:p>

<jats:title>Stars that blow up and bug out</jats:title> <jats:p> When stars move at speeds that will launch them out of our Galaxy, eyes often turn to our core supermassive black hole as the slingshot responsible. For at least one hypervelocity star, however, the galactic center remains innocent. Geier <jats:italic>et al.</jats:italic> traced back the trajectory of a compact helium star, US 708, and deduced a different origin in a binary. In this scenario, US 708 acted as the mass donor in a type Ia supernova pair, which spun US708 to the point of ejection. By knowing this star's exotic past, we learn both about its specific history and about the nature of all type Ia supernovae. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1126" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1259063">1126</jats:related-article> </jats:p>

<jats:title>Listen to the quantum art of noise</jats:title> <jats:p> Electrons in metals are subject to thermally induced noise that can generate tiny magnetic fields. For quantum electronic applications, the noise and magnetic fields can be damaging. Kolkowitz <jats:italic>et al.</jats:italic> show that the spin properties of single defects in diamond can be used to probe the noise. The findings provide insight into how the noise is generated, which could help to mitigate its damaging effects in sensitive quantum electronic circuits. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1129" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa4298">1129</jats:related-article> </jats:p>

<jats:title>A robust paintlike repellent coating</jats:title> <jats:p> Superhydrophobic materials often depend on a particular surface patterning or an applied coating. However, these surfaces can be damaged by wear or fouled by oily materials. Lu <jats:italic>et al.</jats:italic> devised a suspension of coated titanium dioxide nanoparticles that can be spray-painted or dipcoated onto a range of hard and soft surfaces, including paper, cloth, and glass. The coatings resisted rubbing, scratching, and surface contamination. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1132" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa0946">1132</jats:related-article> </jats:p>

<jats:title>Single-protein spectroscopy</jats:title> <jats:p> The spin of a single nitrogen-vacancy (NV) center in diamond is a highly sensitive magnetic-field sensor. Shi <jats:italic>et al.</jats:italic> used the NV center to detect a nitroxidelabeled protein through electron spin resonance under ambient conditions (see the Perspective by Hemmer and Gomes). The strength of the interaction and the details of the hyperfine interaction between the electron and nitrogen spin revealed the position and orientation of the spin label relative to the NV center. The findings also elucidate the dynamical motions of the protein on the diamond surface. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1135" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa2253">1135</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1072" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa7440">1072</jats:related-article> </jats:p>

<jats:title>Cellular diversity in the brain revealed</jats:title> <jats:p> The mammalian brain has an extraordinarily large number of cells. Although there are quite a few different cell types, many cells in any one category tend to look alike. Zeisel <jats:italic>et al.</jats:italic> analyzed the transcriptomes of mouse brain cells to reveal more than meets the eye. Interneurons of similar type were found in dissimilar regions of the brain. Oligodendrocytes that seemed to be all of one class were differentiated by their molecular signatures into a half-dozen classes. Microglia associated with blood vessels were distinguished from look-alike perivascular macrophages. Thus, the complex microanatomy of the brain can be revealed by the RNAs expressed in its cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1138" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa1934">1138</jats:related-article> </jats:p>

<jats:title>Carbon kicked out by nutrients</jats:title> <jats:p> Excess nutrients added to streams result in net carbon loss from aquatic ecosystems. Nitrogen and phosphorus are known to fuel increases in algal carbon. Now, Rosemond <jats:italic>et al.</jats:italic> show that nutrients stimulate losses of terrestrially derived carbon (e.g., from twigs and leaves). The authors monitored several multiyear experiments on headwater forest streams in the United States. Some of these streams had extra nitrogen and phosphorus added at levels that are now common in many streams and lakes. To successfully manage river ecosystems, we need to take into account nutrient pollution effects on multiple carbon pathways. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1142" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa1958">1142</jats:related-article> </jats:p>

<jats:title>Political preferences provide economic capital</jats:title> <jats:p>Longer periods of democratic government favor economic growth, which in turn stabilizes democracy. But is this relationship a given? Fuchs-Schundeln and Schundeln collected individual-level data from more than 100 countries over two decades. Support for democracy did indeed increase as the length of time lived in a democratic system increased.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1145" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa0880">1145</jats:related-article> </jats:p>

<jats:title>A closeup view of the nuclear pore's coat</jats:title> <jats:p> The precise molecular architecture of the nuclear pore complex (NPC), which mediates traffic between the cytoplasm and the nucleus, has been difficult to ascertain owing to the size and complexity of this subcellular structure. Now, Stuwe <jats:italic>et al.</jats:italic> describe the crystal structure of the intact ç400-kD coat nucleoporin complex (CNC) of <jats:italic>Saccharomyces cerevisiae</jats:italic> in the presence of an engineered antibody fragment. Docking the crystal structure into an electron tomography reconstruction of the human NPC established the presence of 32 copies of the CNC arranged in four stacked rings and revealed the details of higher-order CNC oligomerization at the near-atomic level. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1148" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa4136">1148</jats:related-article> </jats:p>