Catálogo de publicaciones - revistas

<jats:title>How to GET to the right membrane</jats:title> <jats:p> Membrane proteins with a hydrophobic transmembrane domain (TMD) play critical roles in virtually all aspects of cell physiology. After it has been synthesized in the cytosol, this TMD must be targeted to and inserted into the correct membrane. The GET pathway is one of two targeting pathways to the endoplasmic reticulum conserved across all eukaryotes. It is not clear how the central targeting factor, Get3, recognizes a TMD to shield it from aggregation until it is successfully inserted into the membrane. Now, Mateja <jats:italic>et al.</jats:italic> show that the functional targeting complex comprises a Get3 dimer bound to a single TMD. The helical hydrophobic TMD binds deep within a large hydrophobic groove in the Get3 dimer. This groove closes slightly upon TMD binding, forming a dynamic “lid” over the mouth of the groove. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1152" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1261671">1152</jats:related-article> </jats:p>

<jats:title>Of mice, men, and macaque brains</jats:title> <jats:p> The human brain represents a unique evolutionary trajectory. To better understand how the human brain came to be, Reilly <jats:italic>et al.</jats:italic> sought to identify changes in gene expression between mice, macaques, and humans. They compared epigenetic marks in the embryonic cortex, which revealed changes in gene regulation in biological pathways associated with cortical development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6226" page="1155" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1260943">1155</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>On this week's show: antimicrobial resistance in low-income countries, and a roundup of daily news stories.</jats:p>