Catálogo de publicaciones - revistas

<jats:title>Circulating signals of drug resistance</jats:title> <jats:p> Cancer drugs often lose their effectiveness because tumors acquire genetic changes that confer drug resistance. Ideally, patients would be switched to a different drug before tumor growth resumes, but this requires early knowledge of how resistance arose. Miyamoto <jats:italic>et al.</jats:italic> have developed a non-invasive method to spot resistance by sequencing RNA transcripts in single circulating tumor cells (CTCs) (see the Perspective by Nanus and Giannakakou). For example, in prostate cancer patients, drug resistance was triggered by activation of the Wnt signaling pathway. But CTCs are rare and fragile, and the technology needs further development before it is used in clinical practice. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6254" page="1351" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aab0917">1351</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6254" page="1283" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aad2448">1283</jats:related-article> </jats:p>

<jats:title>Small peptide regulates protein activity</jats:title> <jats:p> Coding and noncoding RNAs can produce peptides from small open reading frames (smORFs), with a variety of mostly unknown functions. Using a genome-wide screen, Zanet <jats:italic>et al.</jats:italic> show that Polished rice (Pri) smORF peptides control fruit fly development by binding to an E3 ubiquitin ligase. This changes the ligase's selectivity and triggers proteasome-dependent maturation of the developmental transcription factor Shavenbaby. Other smORF peptides may act by a similar mechanism to regulate protein activity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6254" page="1356" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac5677">1356</jats:related-article> </jats:p>

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<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>