Catálogo de publicaciones - revistas

<jats:title>A human spliceosomal subcomplex</jats:title> <jats:p> The spliceosome is an RNA and protein molecular machine that cuts out introns from messenger RNAs. Agafonov <jats:italic>et al.</jats:italic> used cryo-electron microscopy to determine the structure of the largest intermediate subcomplex on the assembly pathway for the human spliceosome (see the Perspective by Cate). The structure shows substantial differences from the equivalent yeast complex. It also reveals how the subcomplex must dock onto the rest of the spliceosome and hints at the structural changes the complex must go through to form the mature spliceosome. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1416" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad2085">1416</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1390" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf4465">1390</jats:related-article> </jats:p>

<jats:title>Methane borylation in a cyclohexane sea</jats:title> <jats:p> Although methane combusts readily at high temperatures, it is generally the hardest hydrocarbon to transform under gentler conditions, owing to its particularly strong C-H bonds. Cook <jats:italic>et al.</jats:italic> now show that soluble rhodium, iridium, and ruthenium catalysts can slice through these C-H bonds to add boron substituents to methane at 150°C. Smith <jats:italic>et al.</jats:italic> report the iridium-catalyzed reaction using phosphine ligands to enhance activity. Both studies were performed in cyclohexane solvent, revealing a remarkable selective preference for the methane reaction over functionalization of the cyclic hydrocarbon. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue pp. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1421" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad9289">1421</jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1424" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad9730">1424</jats:related-article> </jats:p>