Catálogo de publicaciones - revistas

<jats:title>Baby steps toward bNAbs</jats:title> <jats:p> Some HIV-infected individuals develop heavily mutated, broadly neutralizing antibodies (bNAbs) that target HIV. Scientists aim to design vaccines that would elicit such antibodies. Jardine <jats:italic>et al.</jats:italic> report an important step toward this goal: They engineered an immunogen that could engage B cells from HIV-uninfected individuals that express the germline versions of the immunoglobulin genes harbored by a particular class of bNAbs. The frequencies of these B cells, their affinities for the immunogen, and structural analysis suggest that the immunogen is a promising candidate. Further shaping of the B cell response with subsequent immunogens may eventually elicit bNAbs in people. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1458" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad9195">1458</jats:related-article> </jats:p>

<jats:title>The cellular ancestry of tumor antigens</jats:title> <jats:p> One contributing factor in antitumor immunity is the repertoire of neoantigens created by genetic mutations within tumor cells. Like the corresponding mutations, these neoantigens show intratumoral heterogeneity. Some are present in all tumor cells (clonal), and others are present in only a fraction of cells (subclonal). In a study of lung cancer and melanoma, McGranahan <jats:italic>et al.</jats:italic> found that a high burden of clonal tumor neoantigens correlated with improved patient survival, an increased presence of tumor-infiltrating lymphocytes, and a durable response to immunotherapy. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1463" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf1490">1463</jats:related-article> </jats:p>

<jats:title>A proton pump in action</jats:title><jats:p>P-type adenosine triphosphatases (ATPases) use the energy from ATP hydrolysis to pump cations across biological membranes. The electrochemical gradients that are generated control many essential cellular processes. Veshaguri<jats:italic>et al.</jats:italic>incorporated a plant proton pump into vesicles and monitored the dynamics of single pumps. Pumping was stochastically interrupted by long-lived inactive or leaky states. The work reveals how these proton pumps are regulated by a protein domain and by pH gradients.</jats:p><jats:p><jats:italic>Science</jats:italic>, this issue p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6280" page="1469" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad6429">1469</jats:related-article></jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>