Catálogo de publicaciones - revistas

<jats:title>A different gate design</jats:title> <jats:p>The voltage-gated potassium channel Eag1 is overexpressed in tumor cells from a range of cancers, and inhibiting Eag1 reduces tumor growth. Whicher and Mackinnon determined the structure of a mammalian Eag1 bound to the inhibitor calmodulin at 3.78 Å resolution (see the Perspective by Toombes and Swartz). The organization of the voltage-sensing and pore domains differs from that of other potassium channels, indicating that the gating mechanism is distinct. The structure also shows how the channel can be closed by a ligand, independently of the position of the voltage sensor.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="664" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf8070">664</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="646" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aah4194">646</jats:related-article> </jats:p>

<jats:title>The deuteron is too small, too</jats:title> <jats:p> The radius of the proton has remained a point of debate ever since the spectroscopy of muonic hydrogen indicated a large discrepancy from the previously accepted value. Pohl <jats:italic>et al.</jats:italic> add an important clue for solving this so-called proton radius puzzle. They determined the charge radius of the deuteron, a nucleus consisting of a proton and a neutron, from the transition frequencies in muonic deuterium. Mirroring the proton radius puzzle, the radius of the deuteron was several standard deviations smaller than the value inferred from previous spectroscopic measurements of electronic deuterium. This independent discrepancy points to experimental or theoretical error or even to physics beyond the standard model. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="669" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf2468">669</jats:related-article> </jats:p>

<jats:title>Spying a planet in a triple-star system</jats:title> <jats:p> Thousands of extrasolar planets are now known, but only a handful have been detected in direct images. Wagner <jats:italic>et al.</jats:italic> used sophisticated adaptive optics to discover a planet in images of the triple-star system HD 131399 and to take a spectrum of its atmosphere (see the Perspective by Oppenheimer). The planet, about four times the mass of Jupiter, orbits around one star in the system while the other two stars move farther out. This unusual arrangement is puzzling: The planet's orbit may be stable, but it is unclear how it could have formed or migrated there. The results will be used to refine theories of planet formation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="673" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf9671">673</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="644" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aah4097">644</jats:related-article> </jats:p>

<jats:title>Charging up the iron in ferrocene salts</jats:title> <jats:p> Ferrocene is the archetype of the sandwich compounds, so called because a metal atom is inserted between two carbon rings. The elucidation of ferrocene's structure was pivotal to the development of organometallic chemistry during the mid-20th century. The ease with which the iron in the center of the molecule can toggle between the +2 and +3 oxidation states has made the compound a common electrochemical standard. Malischewski <jats:italic>et al.</jats:italic> report the synthesis and isolation of ferrocene salts with iron in the +4 state, which they characterize crystallographically and spectroscopically. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="678" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf6362">678</jats:related-article> </jats:p>

<jats:title>Soft and still responsive</jats:title> <jats:p> Transparent touch screens, from large-panel interactive information maps to advanced cell phones, have become a part of daily life. However, such devices all use hard materials. Kim <jats:italic>et al.</jats:italic> have developed a soft touch panel based on polyacrylamide hydrogels (cross-linked polymers swollen with water) that are highly transparent and contain trapped LiCl to enhance conductivity. The hydrogels are soft and can be stretched extensively while still maintaining touch sensitivity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="682" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf8810">682</jats:related-article> </jats:p>

<jats:title>Circadian rhythms and sleep deprivation</jats:title> <jats:p> Sleep deprivation, such as that experienced because of shift work, jet lag, sleep disorders, and aging, leads to deterioration of many aspects of health. Cognition deteriorates rapidly and substantially when we stay awake through the night. To investigate the time course of brain responses during sleep loss, Muto <jats:italic>et al.</jats:italic> scanned volunteers repeatedly during an extended period of wakefulness (see the Perspective by Czeisler) in which circadian and homeostatic drives differentially affected local brain regions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="687" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aad2993">687</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="648" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aah5402">648</jats:related-article> </jats:p>

<jats:title>Building new networks in the brain</jats:title> <jats:p> Donald Hebb's hypothesis that coactivation of neurons leads to the formation of ensembles of neurons has inspired neuroscientists for decades. The experimental creation of such ensembles has been technically challenging. Using two-photon optogenetic stimulation with single-cell resolution, Carrillo-Reid <jats:italic>et al.</jats:italic> discovered that recurrent activation of a group of neurons creates an ensemble that is imprinted in the brain circuitry. Activation of a single neuron can lead to recall of the entire ensemble in a phenomenon called pattern completion. The artificial ensemble persists over days and can be reactivated at later time points without interfering with endogenous circuitry. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="691" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf7560">691</jats:related-article> </jats:p>

<jats:title>Programs that buffer a financial shock work</jats:title> <jats:p> For people without a safety net of social and financial resources, a shock, such as medical expenses not covered by insurance, can be the first step in a downward spiral toward homelessness and morbidity. Evans <jats:italic>et al.</jats:italic> evaluate the effectiveness and cost of a program in Chicago that provides temporary financial assistance with the aim of enabling individuals to stay in their homes and out of homeless shelters. They find that one-time payments of up to $1500 greatly reduce the likelihood of homelessness. The estimated economic benefits exceed the estimated costs, with immeasurable psychic and physical benefits. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="694" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aag0833">694</jats:related-article> </jats:p>

<jats:title>Active fatty acid layers</jats:title> <jats:p> Saturated fatty acids are considered to be inert, but they can be surprisingly reactive when present as a coating at an air-water interface. Rossignol <jats:italic>et al.</jats:italic> show that nonanoic acid is photochemically active when it is present as a monolayer on a water surface (see the Perspective by Vaida). Fatty acids are ubiquitous in the environment, and their photochemical processing could have a substantial impact on local ozone and particle formation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="699" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf3617">699</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="650" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aah4111">650</jats:related-article> </jats:p>