Catálogo de publicaciones - revistas

<jats:title>Deep living for centuries</jats:title> <jats:p> We tend to think of vertebrates as living about as long as we do, give or take 50 to 100 years. Marine species are likely to be very long-lived, but determining their age is particularly difficult. Nielsen <jats:italic>et al.</jats:italic> used the pulse of carbon-14 produced by nuclear tests in the 1950s—specifically, its incorporation into the eye during development—to determine the age of Greenland sharks. This species is large yet slow-growing. The oldest of the animals that they sampled had lived for nearly 400 years, and they conclude that the species reaches maturity at about 150 years of age. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="702" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf1703">702</jats:related-article> </jats:p>

<jats:title>Water dissolving and water removing</jats:title> <jats:p> Not all groundwater ends up flowing into rivers. Some is discharged directly into the ocean along the coast. Although much lower in volume than water transported by rivers, such submarine groundwater discharge can be a hidden source of dissolved ions, nutrients, or contaminants from human activities. Sawyer <jats:italic>et al.</jats:italic> performed a high-resolution continental-scale analysis of fresh groundwater discharge along the coastline of the United States. In total, more than one-fifth of coastal waters are vulnerable to groundwater-borne contamination. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="705" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aag1058">705</jats:related-article> </jats:p>

<jats:title>Targeting three defects with one strategy</jats:title> <jats:p> The neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia are most commonly caused by a mutation in the <jats:italic>C9orf72</jats:italic> gene. The mutation is an expanded hexanucleotide repeat in a noncoding region. The expanded repeat produces sense and antisense RNA transcripts, which accumulate in patient cells and appear to sequester RNA-binding proteins. The sense and antisense transcripts are also translated into dipeptide repeat proteins, which are aggregation-prone and accumulate in the brain and spinal cord. Last, loss of function from reduced expression of <jats:italic>C9orf72</jats:italic> in neurons and glia could contribute to the disease. Kramer <jats:italic>et al.</jats:italic> targeted both sense and antisense repeats by blocking a single gene called <jats:italic>SPT4</jats:italic> , which mitigated degeneration in human cells by reducing all three types of pathologies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6300" page="708" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf7791">708</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>