Catálogo de publicaciones - revistas

<jats:title>A global genetic suppression network</jats:title> <jats:p> The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen <jats:italic>et al.</jats:italic> generated a large-scale suppression network in yeast. The data set reveals a set of general properties that can be used to predict suppression interactions. Furthermore, the study provides a template for extending suppression studies to other genes or to more complex organisms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6312/aag0839.full">599</jats:ext-link> </jats:p>

<jats:title>Complex transcription factor interactions</jats:title> <jats:p> To respond to environmental changes, such as drought, plants must regulate numerous cellular processes. Working in the model plant <jats:italic>Arabidopsis</jats:italic> , Song <jats:italic>et al.</jats:italic> profiled the binding of 21 transcription factors to chromatin and mapped the complex gene regulatory networks involved in the response to the plant hormone abscisic acid. The work provides a framework for understanding and modulating plant responses to stress. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6312/aag1550.full">598</jats:ext-link> </jats:p>