Catálogo de publicaciones - revistas

<jats:title>Radicals push proteins beyond genes</jats:title> <jats:p> Chemically modifying proteins after their translation can expand their structural and functional roles (see the Perspective by Hofmann and Bode). Two related methods describe how to exploit free radical chemistry to form carbon-carbon bonds between amino acid residues and a selected functional group. Wright <jats:italic>et al.</jats:italic> added a wide range of functional groups to proteins containing dehydroalanine precursors, with borohydride mediating the radical chemistry. Yang <jats:italic>et al.</jats:italic> employed a similar approach, using zinc in combination with copper ions. Together, these results will be useful for introducing functionalities and labels to a wide range of proteins. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue pp. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6312/aag1465.full">597</jats:ext-link> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6312" page="623" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aah4428">623</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6312" page="553" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aai8788">553</jats:related-article> </jats:p>

<jats:title> Scientific impact—that is the <jats:italic>Q</jats:italic> </jats:title> <jats:p> Are there quantifiable patterns behind a successful scientific career? Sinatra <jats:italic>et al.</jats:italic> analyzed the publications of 2887 physicists, as well as data on scientists publishing in a variety of fields. When productivity (which is usually greatest early in the scientist's professional life) is accounted for, the paper with the greatest impact occurs randomly in a scientist's career. However, the process of generating a high-impact paper is not an entirely random one. The authors developed a quantitative model of impact, based on an element of randomness, productivity, and a factor <jats:italic>Q</jats:italic> that is particular to each scientist and remains constant during the scientist's career. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6312/aaf5239.full">596</jats:ext-link> </jats:p>

<jats:p>Since 2000, almost half a million Americans have died from drug overdoses. This modern plague—largely driven by opioid addiction—degrades health, saps productivity, spawns crime, and devastates families, all at enormous societal cost. How did we get here, and what do we do now?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Models may underestimate the pace of ice loss because they are missing Arctic warming</jats:p>

<jats:p>Hundreds of scientists paid fees to have their work featured on Benefunder, but very few received donations</jats:p>

<jats:p>Modest success in Thailand inspires South Africa trial</jats:p>

<jats:p>Controversy swirls around fossil, which is no longer accessible</jats:p>

<jats:p>New NSF survey finds that California has widened its lead over the rest of the country in state-by-state analysis of what companies spend on research.</jats:p>