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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Update: Florida voters split on releasing GM mosquitoes
Kelly Servick
Palabras clave: Multidisciplinary.
Pp. No disponible
This ‘muddy dragon’ may have met its end in a Chinese slush pit
Carolyn Gramling
Palabras clave: Multidisciplinary.
Pp. No disponible
Top stories: What a Trump presidency means for science, rats giggle when tickled, and more
Rachel Lallensack
Palabras clave: Multidisciplinary.
Pp. No disponible
Government pot is less potent than commercial pot, questioning dozens of scientific studies
Michael Price
Palabras clave: Multidisciplinary.
Pp. No disponible
For linguists, the new sci-fi film <i>Arrival</i> can't come soon enough
Brice Russ
Palabras clave: Multidisciplinary.
Pp. No disponible
A computer program just ranked the most influential brain scientists of the modern era
John Bohannon
Palabras clave: Multidisciplinary.
Pp. No disponible
Update: Controversial ‘four-legged snake’ may be ancient lizard instead
Carolyn Gramling
Palabras clave: Multidisciplinary.
Pp. No disponible
Embryonic stem cells and fetal tissue research—will Trump intervene?
Kelly Servick
Palabras clave: Multidisciplinary.
Pp. No disponible
De novo design of a biologically active amyloid
Rodrigo Gallardo; Meine Ramakers; Frederik De Smet; Filip Claes; Ladan Khodaparast; Laleh Khodaparast; José R. Couceiro; Tobias Langenberg; Maxime Siemons; Sofie Nyström; Laurence J. Young; Romain F. Laine; Lydia Young; Enrico Radaelli; Iryna Benilova; Manoj Kumar; An Staes; Matyas Desager; Manu Beerens; Petra Vandervoort; Aernout Luttun; Kris Gevaert; Guy Bormans; Mieke Dewerchin; Johan Van Eldere; Peter Carmeliet; Greetje Vande Velde; Catherine Verfaillie; Clemens F. Kaminski; Bart De Strooper; Per Hammarström; K. Peter R. Nilsson; Louise Serpell; Joost Schymkowitz; Frederic Rousseau
<jats:title>Aggregation by design</jats:title> <jats:p> Amyloid aggregation is driven by short sequences within proteins that self-assemble into characteristic amyloid structures. About 30 human proteins are implicated in amyloid-associated diseases, but many more contain short sequences that are potentially amyloidogenic. Gallardo <jats:italic>et al.</jats:italic> designed a peptide based on an amyloidogenic sequence in the vascular endothelial growth factor receptor VEGFR2. The peptide induced VEGFR2 to form aggregates with features characteristic of amyloids. Amyloids were toxic only in cells that required VEGFR2 activity, suggesting that the toxicity was due to loss of function of VEGFR2, rather than to inherent toxicity of the aggregates. The peptide inhibited VEGFR2-dependent tumor growth in a mouse tumor model. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aah4949">10.1126/science.aah4949</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
The broad footprint of climate change from genes to biomes to people
Brett R. Scheffers; Luc De Meester; Tom C. L. Bridge; Ary A. Hoffmann; John M. Pandolfi; Richard T. Corlett; Stuart H. M. Butchart; Paul Pearce-Kelly; Kit M. Kovacs; David Dudgeon; Michela Pacifici; Carlo Rondinini; Wendy B. Foden; Tara G. Martin; Camilo Mora; David Bickford; James E. M. Watson
<jats:title>Accumulating impacts</jats:title> <jats:p> Anthropogenic climate change is now in full swing, our global average temperature already having increased by 1°C from preindustrial levels. Many studies have documented individual impacts of the changing climate that are particular to species or regions, but individual impacts are accumulating and being amplified more broadly. Scheffers <jats:italic>et al.</jats:italic> review the set of impacts that have been observed across genes, species, and ecosystems to reveal a world already undergoing substantial change. Understanding the causes, consequences, and potential mitigation of these changes will be essential as we move forward into a warming world. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaf7671">10.1126/science.aaf7671</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible