Catálogo de publicaciones - revistas

<jats:p>A new tome argues that the ancient Babylonians deserve greater recognition in scientific histories</jats:p>

<jats:p> Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from <jats:italic>Chaetomium thermophilum</jats:italic> . This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect. </jats:p>

<jats:p> Zhang <jats:italic>et al</jats:italic> . suggested that in the crystal structure of a polycomb repressive complex 2 from <jats:italic>Chaetomium thermophilum</jats:italic> ( <jats:italic>ct</jats:italic> PRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of <jats:italic>ct</jats:italic> PRC2 bound to a bona fide H3K27M sequence. </jats:p>

<jats:p>Program fosters dialogue between scientific and religious communities</jats:p>