Catálogo de publicaciones - revistas

<jats:title>Diverse molecular choreography of replication</jats:title> <jats:p> Accurate duplication and transmission of genetic information to the next generation requires complex molecular assemblies. Bleichert <jats:italic>et al.</jats:italic> review replication initiation across the three domains of life, with a focus on origin selection and helicase loading. These processes identify potential origins of replication and prepare them for subsequent bidirectional replication initiation. There are key similarities and multiple differences in replication mechanisms between eukaryotes, prokaryotes, and archaea and many outstanding questions to be answered. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6327" page="eaah6317" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aah6317">eaah6317</jats:related-article> </jats:p>

<jats:title>DNA charged with regulating replication</jats:title> <jats:p> DNA can transport electrical charge over long distances and has the potential to act as a signaling system. The iron-sulfur complex [4Fe4S] found in some proteins is known to be involved in redox reactions. The eukaryotic DNA primase is involved in DNA replication and contains a [4Fe4S] cluster that is required for its RNA primer synthesis activity. O'Brien <jats:italic>et al.</jats:italic> show that the [4Fe4S] cluster in DNA primase can regulate the protein's DNA binding activity through DNA-mediated charge transfer. This in turn plays a role in primer initiation and length determination. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6327" page="eaag1789" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aag1789">eaag1789</jats:related-article> </jats:p>

<jats:p>As the Trump administration takes shape, there is much speculation as to what major changes will be made. A dominant theme of the Trump campaign was to cut through bureaucracy in Washington, D.C., thereby enhancing innovation and bringing new technology to Americans more quickly. Nowhere could such a philosophical change have more impact than on Food and Drug Administration (FDA) approval of new drugs.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Researchers await data from the satellite company Planet, which has launched a flotilla of tiny eyes in the sky that will soon image the entire globe every day.</jats:p>

<jats:p>Citing protocol violations, institute won't allow use of 25 years of data.</jats:p>

<jats:p>ELI's plans for a 200-petawatt laser quietly postponed.</jats:p>

<jats:p>Widely anticipated decision affirms Broad Institute's claim to genome editing in human cells, but the battle is not over.</jats:p>

<jats:p>Forecasts of moisture conduits could aid water managers.</jats:p>

<jats:p>As algae, detritus, and meltwater darken Greenland's ice, it is shrinking ever faster.</jats:p>