Catálogo de publicaciones - revistas

<jats:title>Self-organization for sensory brushes</jats:title> <jats:p> Sensory hairs on the back of a fruit fly are lined up in neat rows. The orderliness of this arrangement has encouraged models based on organized specification of the hairs. Corson <jats:italic>et al.</jats:italic> now show that development is both less precise and more effective than that. They used mathematical modeling to recapitulate genetic effects as the developing epidermis becomes organized into enough rows and single lines of hairs. Their work suggests that the sensory field develops through self-organizing patterning that can adjust to the size of the epidermis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6337" page="eaai7407" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aai7407">eaai7407</jats:related-article> </jats:p>

<jats:title>Positives and negatives of methylated CpG</jats:title> <jats:p> When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide. This modification alters DNA structure but can also affect function by inhibiting transcription factor (TF) binding. Yin <jats:italic>et al.</jats:italic> systematically analyzed the effect of CpG methylation on the binding of 542 human TFs (see the Perspective by Hughes and Lambert). In addition to inhibiting binding of some TFs, they found that mCpGs can promote binding of others, particularly TFs involved in development, such as homeodomain proteins. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6337" page="eaaj2239" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aaj2239">eaaj2239</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6337" page="489" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aan2927">489</jats:related-article> </jats:p>

<jats:title>Wet, soft, squishy, and tunable</jats:title> <jats:p>Hydrogels are highly cross-linked polymer networks that are heavily swollen with water. Hydrogels have been used as dynamic, tunable, degradable materials for growing cells and tissues. Zhang and Khademhosseini review the advances in making hydrogels with improved mechanical strength and greater flexibility for use in a wide range of applications.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6337" page="eaaf3627" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aaf3627">eaaf3627</jats:related-article> </jats:p>

<jats:p>On 22 April, many thousands of people took part in demonstrations, teach-ins, museum open houses, and science festivals in hundreds of places around the world—an unparalleled show of support for science. Some journalists have tried to portray the march as yet another political demonstration against President Trump and Congress. Yet, neither appeared to be the target for most marchers—not in the United States and even less so around the world. That the March for Science saw the scientific community and the wider public come together in unprecedented numbers signaled that the day was not just a protest by scientists with concerns about their funding or job security. The multitude of T-shirt slogans, placards, and impassioned remarks by marchers and speakers of all ages, backgrounds, and professions spoke volumes—something serious was going on.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Legislators ignore Trump's call for cuts and give NIH, NASA research big increases</jats:p>