Catálogo de publicaciones - revistas

<jats:title>Disrupting housefly gene reverses sex</jats:title> <jats:p> Sex comes in many forms, even when considered at the molecular level. In different animals, the chromosomes and specific genes that function in sex determination vary widely. As a case in point, the familiar housefly displays a highly variable sex determination system. In this animal, the male determiner (M-factor) instructs male development when it is active, but female development results when it is inactive. Sharma <jats:italic>et al.</jats:italic> now identify the housefly M-factor, which arose via the co-option of existing genes, gene duplication, and neofunctionalization. The findings elucidate the remarkable diversity in sex-determining pathways and the forces that drive this diversity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6338" page="642" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aam5498">642</jats:related-article> </jats:p>

<jats:p> Metabolomics—the study of the collection of an organism’s metabolites—provides a molecular measurement of phenotype, or the characteristics resulting from the genotype’s interaction with the environment. Using a range of analytical tools to scale the mountains of data collected, including molecular detection and bioinformatics, scientists use metabolomics to understand systems biology, which is the complete computational analysis and modeling of an organism and its well-being. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/custom-publishing/technology-features/big-data-big-picture-metabolomics-meets-systems-biology">Read the Feature (Full-Text HTML)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/custom-publishing/documents/12MayMetabolomicsFeature_R2.pdf">Read the Feature (PDF)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/custom-publishing/douments/12MayNewProducts.pdf">Read New Products (PDF)</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> The discovery of the CRISPR/Cas9 system in bacteria has ignited the world of gene editing. It has been applied to the modification of a growing range of organisms, with none found yet that can resist its powers. In particular, CRISPR technology has revolutionized the process for creating genetically modified mice—the workhorses for in vivo cancer research—allowing for shorter timelines and in many cases, more efficient procedures. In this webinar, our expert panel will discuss the strengths and benefits of CRISPR technology, how it differs from more traditional techniques, and some of the specific challenges it creates. They will share their at-the-bench experiences with viewers, providing practical, actionable information for researchers wanting to apply CRISPR technology to mouse-model generation, particularly for use in cancer research. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/custom-publishing/webinars/generating-crispr-mouse-models-challenges-and-solutions">View the Webinar</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>