Catálogo de publicaciones - revistas

<jats:title>Detecting unusual oscillations</jats:title> <jats:p> Under the influence of a constant force, an electron in the periodic potential of a crystal lattice undergoes so-called Bloch oscillations. The same phenomenon has been seen with ultracold atoms in optical lattices, but it is not expected to occur in a uniform system. Meinert <jats:italic>et al</jats:italic> . observed Bloch oscillations of an impurity atom in one-dimensional tubes of strongly interacting cesium atoms—a system without built-in periodicity. Owing to the strong interactions, the bosonic atoms stayed away from one another, forming an effective lattice. The researchers observed reflections of the impurity atoms of this effective lattice in momentum space, with the lattice constant corresponding to the interatomic distance of the host gas. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6341" page="945" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aah6616">945</jats:related-article> </jats:p>

<jats:p>Massive methane blow-outs may be responsible for clusters of kilometer-wide craters in the Barents Sea.</jats:p>

<jats:title>Localizing light at the nanometer scale</jats:title><jats:p>Waves will propagate through a medium until scattering processes result in the excitation gradually dying away. Introducing disorder can affect that propagation by increasing the scattering, potentially reaching a point where transport is stopped. Typically, the length scale of the disorder is larger than the propagating waves. Herzig Sheinfux<jats:italic>et al</jats:italic>. now show that a stack of several-nanometer-thick layers of alternating high- and low-refractive- index material can result in the localization of light. Such deep-subwavelength structures could provide a route to manipulating light on the nanometer scale.</jats:p><jats:p><jats:italic>Science</jats:italic>, this issue p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6341" page="953" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aah6822">953</jats:related-article></jats:p>

<jats:title>A versatile synthesis of pleuromutilin</jats:title> <jats:p> Synthetic flexibility is crucial for antibiotic development, because numerous subtle structural variations can contribute to combating resistant strains. A derivative of the fungal natural product pleuromutilin was approved a decade ago for treatment of Gram-positive bacterial skin infections; recent efforts to tune the structure for activity against Gram-negative bacteria have focused on the stereochemistry at a particular carbon center. Murphy <jats:italic>et al</jats:italic> . present a synthetic route to pleuromutilin that allows the configurations in that segment of the molecule to be varied, offering a distinct path for structural optimization. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6341" page="956" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aan0003">956</jats:related-article> </jats:p>

<jats:title>Probing the structure of the magnetopause</jats:title> <jats:p> The magnetopause is the boundary in space that separates the region dominated by Earth’s magnetic field (the magnetosphere) from the surrounding solar wind. The four spacecraft of NASA’s Magnetospheric Multiscale (MMS) mission have repeatedly flown in formation through the magnetopause, measuring the properties of the plasma and magnetic fields in the region. Russell <jats:italic>et al</jats:italic> . used MMS measurements to study the magnetopause’s structure and force balance. They identified small-scale dynamic features that form a complex topology and evidence for magnetic flux ropes at the boundary. The results aid our understanding of Earth’s space environment and magnetospheres around other planets. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6341" page="960" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aag3112">960</jats:related-article> </jats:p>

<jats:p>Light-driven rotation of two components in a molecular motor couples synchronously with the motion of a third component.</jats:p>

<jats:p>Effects of a lipid signaling molecule depend on its subcellular location.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>The immune system plays a critical role not only in fending off pathogen attack, but also in cancer surveillance, and more recently as a tool in immunotherapy-based treatments. Immune cell functions are tightly regulated by essential transcription factors such as NF-κB and NFAT. Monitoring immune cell activity—including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production—can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system. Imaging flow cytometry (IFC) has emerged as a useful and efficient tool for studying the signaling pathways in immunophenotypically defined subpopulations of immune cells. This technique enables quantitative image analysis of the intracellular localization of the signaling intermediaries NF-κB and NFAT as parameters of immune activity. This webinar will introduce viewers to the process of using IFC to determine subcellular localization of biomarkers, including a discussion of how IFC can help to assess the activity of transcription factors, or the drug-induced stimulation or inhibition thereof, in clinical samples.</jats:p>