Catálogo de publicaciones - revistas

<jats:title>Swapping boron acids for carbon acids</jats:title> <jats:p> Carbon-bound boronic acids and their esters are widely used as coupling partners to make carbon-carbon bonds. More recently, these chemicals have garnered pharmaceutical interest in their own right. Li <jats:italic>et al.</jats:italic> report a versatile nickel-catalyzed process to replace carboxylic acids with boronate esters by using a phthalimide activator. The reaction is well suited to late-stage modification of complex molecules. The authors used the approach to produce a potent in vitro inhibitor of human neutrophil elastase, a target of interest in treating inflammatory lung diseases. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6342" page="eaam7355" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aam7355">eaam7355</jats:related-article> </jats:p>

<jats:title>Bacterial sensing mechanism revealed</jats:title> <jats:p> <jats:italic>Escherichia coli</jats:italic> use a transmembrane sensor protein to sense nitrate in their external environment and initiate a biochemical response. Gushchin <jats:italic>et al.</jats:italic> compared crystal structures of portions of the NarQ receptor that included the transmembrane helices in ligand-bound or unbound states. The structures suggest a signaling mechanism by which piston- and lever-like movements are transmitted to response regulator proteins within the cell. Such two-component systems are very common in bacteria and, if better understood, might provide targets for antimicrobial therapies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6342" page="eaah6345" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aah6345">eaah6345</jats:related-article> </jats:p>

<jats:title>Tracing development of the dendritic cell lineage</jats:title> <jats:p> Dendritic cells (DCs) are important components of the immune system that form from the bone marrow into two major cell lineages: plasmacytoid DCs and conventional DCs. See <jats:italic>et al.</jats:italic> applied single-cell RNA sequencing and cytometry by time-of-flight to characterize the developmental pathways of these cells. They identified blood DC precursors that shared surface markers with plasmacytoid DCs but that were functionally distinct. This unsuspected level of complexity in pre-DC populations reveals additional cell types and refines understanding of known cell types. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6342" page="eaag3009" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aag3009">eaag3009</jats:related-article> </jats:p>

<jats:p>The Trump administration aims to eliminate many regulations and make it more difficult to adopt new ones. More subtle and dangerous are attempts in Congress to undermine public health and environmental protections by limiting the use of scientific evidence under the guise of increased transparency. This effort, which as envisioned by U.S. Environmental Protection Agency (EPA) leadership would greatly reduce the amount of science used in decision-making, undermines the credibility and application of scientific evidence, weakens the scientific enterprise, and imperils public and environmental health.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p> New fossils and dates put a face on early <jats:italic>Homo sapiens</jats:italic> . </jats:p>

<jats:p>Government appoints loyalists to four councils, limits foreign influence.</jats:p>

<jats:p>Studies hint at health and disease roles of unusual DNAs.</jats:p>

<jats:p>Agency-backed analysis led to policy move to cap grant support for big labs.</jats:p>