Catálogo de publicaciones - revistas

<jats:title>Metabolic programming of tissue APCs</jats:title> <jats:p> Antigen-presenting cells (APCs) are scattered throughout the body in lymphoid organs and at the portals of pathogen entry, where they act as sentinels of the immune system. Sinclair <jats:italic>et al.</jats:italic> demonstrate that APCs at different sites have distinctive metabolic signatures and that the development and function of these cells are determined not only by their transcriptional program, but also by their metabolic state (see the Perspective by Wiesner and Klein). The authors identified a central role for mTOR in mediating the metabolic adaptation of such tissue-resident APCs by influencing the immunological character of allergic inflammation. Thus, tissues endow resident APCs with distinctive metabolic characteristics that control APC development and function. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1014" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aaj2155">1014</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="973" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao3086">973</jats:related-article> </jats:p>

<jats:title>A homodimeric complex for anaerobic photosynthesis</jats:title> <jats:p> In plants, algae, and cyanobacteria, large molecular complexes—photosystems I and II—convert light energy into chemical energy, releasing oxygen as a by-product. This oxygenic photosynthesis is critical for maintaining Earth's atmospheric oxygen. At their cores, photosystems I and II contain a heterodimeric reaction center. Reaction centers evolved in an atmosphere lacking oxygen, and the ancestral complex was likely homodimeric, encoded by a single gene. Gisriel <jats:italic>et al.</jats:italic> describe the structure of a homodimeric reaction center from an anoxygenic photosynthetic bacterium. The structure shows perfect symmetry of the light-collecting antennae and elucidates the electron transfer chain. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1021" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan5611">1021</jats:related-article> </jats:p>

<jats:title>Family ties reveal original planetesimals</jats:title> <jats:p> The asteroid belt originated from leftover debris from the formation of our solar system, including objects that never grew big enough to become planets. Destructive collisions led to the present proliferation of asteroids; groups that were initially part of the same body have related orbits and are known as families. Delbo' <jats:italic>et al.</jats:italic> identified an ancient family mostly consisting of dark asteroids that previously had not been linked to families (see the Perspective by DeMeo). From this, they calculated the original population of the belt, showing that it contained several dozen midsized bodies known as planetesimals. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1026" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam6036">1026</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="972" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao1141">972</jats:related-article> </jats:p>