Catálogo de publicaciones - revistas

<jats:title>A ductile steel shows its strength</jats:title> <jats:p> Many industrial applications require materials to have high strength while remaining pliable, or ductile. However, the microstructure that increases strength tends to reduce ductility. He <jats:italic>et al.</jats:italic> used a processing mechanism to create a “forest” of line defects in manganese steel. This deformed and partitioned steel was produced by cold-rolling and low-temperature annealing and contained a dislocation network that improved both strength and ductility. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1029" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0177">1029</jats:related-article> </jats:p>

<jats:title>A different form of synaptic plasticity</jats:title> <jats:p> How do synaptic or other neuronal changes support learning? This subject has been dominated by Hebb's postulate of synaptic change. Although there is strong experimental support for Hebbian plasticity in a number of preparations, alternative ideas have also been developed over the years. Bittner <jats:italic>et al.</jats:italic> provide in vivo, in vitro, and modeling data to support the view that non-Hebbian plasticity may underlie the formation of hippocampal place fields (see the Perspective by Krupic). Instead of multiple pairings, a single strong Ca <jats:sup>2+</jats:sup> plateau potential in neuronal dendrites paired with spatial inputs may be sufficient to produce place cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1033" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan3846">1033</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="974" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao4159">974</jats:related-article> </jats:p>

<jats:title>Survivin' neutrophil surveillance</jats:title> <jats:p> Humans constantly inhale fungal spores. Why don't we suffer more invasive infections from ubiquitous fungal molds such as <jats:italic>Aspergillus fumigatus</jats:italic> ? Working in mice, Shlezinger <jats:italic>et al.</jats:italic> found that neutrophils phagocytosed germinating fungal spores deep in the lungs (see the Perspective by Wiesner and Klein). Once engulfed, the fungal cells underwent programmed cell death, likely induced by phagocyte NADPH oxidase. Fungal strains engineered to overexpress a fungal <jats:italic>survivin</jats:italic> homolog resisted cell death by inhibiting caspase-3 and -7. When a Survivin antagonist was applied, more fungal cells died. These findings may lead to therapies for immunocompromised patients threatened by invasive fungal lung infections. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1037" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0365">1037</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="973" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao3086">973</jats:related-article> </jats:p>

<jats:title>Life under threat of deportation</jats:title> <jats:p> What is the effect on a child of having parents who are at risk of deportation as unauthorized immigrants? Hainmueller <jats:italic>et al.</jats:italic> developed a quasi-experimental protocol to address this complicated question. They selected mothers who had birthdates either just before or just after the cutoff for the United States' Deferred Action for Childhood Arrivals (DACA) program. Children whose mothers were protected from deportation by DACA had 50% fewer diagnoses of adjustment and anxiety disorder than children with mothers whose birthdates, by coincidence, preceded the cutoff and who thus were not protected. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1041" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan5893">1041</jats:related-article> </jats:p>

<jats:title>Building-blind bats</jats:title> <jats:p> Human-generated structures now dominate much of the planet, but they have existed for but a blink of an eye from an evolutionary perspective. Animal sensory systems evolved to navigate natural environments and so may not always be reliable in anthropogenic ones. Greif <jats:italic>et al.</jats:italic> show that echolocating bats appear to perceive smooth vertical surfaces as open areas, a mistake that often leads to collisions (see the Perspective by Stilz). With millions upon millions of smooth vertical surfaces in our world today, such misperceptions could have considerable negative impacts on bat survival. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1045" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam7817">1045</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="977" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao2989">977</jats:related-article> </jats:p>

<jats:title>Foiling bad bugs' sneaky tricks</jats:title> <jats:p> Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel <jats:italic>et al.</jats:italic> show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1047" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aal4677">1047</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="976" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao4158">976</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>