Catálogo de publicaciones - revistas

<jats:title>Fattening up proteins</jats:title> <jats:p> Many eukaryotic proteins are modified by the attachment of lipids, and these modifications can alter how proteins interact with cellular membranes. Rana <jats:italic>et al.</jats:italic> present x-ray crystal structures of an integral membrane enzyme that appends a fatty acyl chain onto a cysteine residue of target proteins. The enzyme active site is situated at the membrane surface, thus explaining the enzyme's preference for substrates that are already membrane-associated. The structure of a fatty acid-like inhibitor bound within a hydrophobic cavity elucidates the mechanism for the enzyme's acyl chain specificity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6372" page="eaao6326" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao6326">eaao6326</jats:related-article> </jats:p>

<jats:p> It was 200 years ago that Mary Shelley's <jats:italic>Frankenstein; or, The Modern Prometheus</jats:italic> was published. Over the decades, this gothic tale has captured the popular imagination through the numerous theater productions and films it inspired. The story is commonly taken to imply a dire warning about the dangers of scientific hubris. Just mention the name Frankenstein and laypersons think of scientists “playing God.” In the common view, the inevitable consequence of Frankenstein's alleged transgression—bestowing life on inanimate matter—was that he created a monster that would wreak havoc on his family and friends. Frankenstein's name is repeatedly invoked in debates about emerging technologies like biotech, nanotech, synthetic biology, and artificial intelligence. However, the view of Shelley's story as a cautionary tale about scientific hubris, although dominant, is only one possible interpretation. Her novel, actually, is a multilayered story full of ambivalences and much subtler than most Hollywood versions. It naturally lends itself to diverse interpretations. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>As quantum supremacy nears, so does a desire to apply machines to science problems.</jats:p>

<jats:p>Cases are the lowest ever, but the virus persists in sewage.</jats:p>

<jats:p>Report urges NASA to choose medium-size Earth-observing satellites through competition to keep costs down.</jats:p>

<jats:p>Nation seeks assistance for project to strengthen coastal defenses and relocate villages.</jats:p>

<jats:p>Buried glaciers could be prime target for human exploration.</jats:p>

<jats:p>Mary Shelley's 200-year-old tale is still essential reading for scientists.</jats:p>

<jats:p>A novel offers grist for psychologists and science historians, ammunition for technophobes, and even inspiration for researchers.</jats:p>