Catálogo de publicaciones - revistas

<jats:title>Live imaging of DNA loop extrusion</jats:title> <jats:p> To spatially organize chromosomes, ring-shaped protein complexes including condensin and cohesin have been hypothesized to extrude DNA loops. Condensin has been shown to exhibit a DNA-translocating motor function, but extrusion has not been observed directly. Using single-molecule imaging, Ganji <jats:italic>et al.</jats:italic> visualized in real time a condensin-mediated, adenosine triphosphate-dependent, fast DNA loop extrusion process. Loop extrusion occurred asymmetrically, with condensin reeling in only one end of the DNA. These data provide unambiguous evidence of a loop extrusion mechanism for chromosome organization. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6384" page="102" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aar7831">102</jats:related-article> </jats:p>

<jats:title>Signaling hematopoietic stem cells from afar</jats:title> <jats:p> Throughout our entire life span, hematopoietic stem cells (HSCs) generate all of our blood cells. The bone marrow microenvironment, or niche, is key to activating stem cell activity. Decker <jats:italic>et al.</jats:italic> now show that thrombopoietin generated in the liver, but not from the local bone marrow niche, maintains HSCs in vivo in mice. Thus, systemic endocrine factors are needed to maintain somatic stem cells from a distance. These findings may be important when considering how to stimulate HSCs for therapeutic use. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6384" page="106" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aap8861">106</jats:related-article> </jats:p>

<jats:title>Revisiting the origins of modern horses</jats:title> <jats:p> The domestication of horses was very important in the history of humankind. However, the ancestry of modern horses and the location and timing of their emergence remain unclear. Gaunitz <jats:italic>et al.</jats:italic> generated 42 ancient-horse genomes. Their source samples included the Botai archaeological site in Central Asia, considered to include the earliest domesticated horses. Unexpectedly, Botai horses were the ancestors not of modern domestic horses, but rather of modern Przewalski's horses. Thus, in contrast to current thinking on horse domestication, modern horses may have been domesticated in other, more Western, centers of origin. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6384" page="111" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aao3297">111</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>