Catálogo de publicaciones - revistas

<jats:title>The mitoCPR unclogs mitochondria</jats:title> <jats:p>The import of proteins into mitochondria is essential for cell viability. How cells respond when mitochondrial protein import is impaired is poorly understood. Weidberg and Amon showed that upon mitochondrial import stress, yeast cells mounted a response known as the mitoCPR. mitoCPR was activated when mitochondrial protein import was impaired and unimported precursors accumulated on the organelle's surface. mitoCPR restored mitochondrial functions by clearing stalled proteins from the import channels. It did this by inducing expression of Cis1, which recruited the adenosine triphosphatase Msp1 to import channels to remove unimported precursors and target them for degradation by the proteasome.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aan4146">eaan4146</jats:related-article> </jats:p>

<jats:title>Writing a cell's history in its DNA</jats:title> <jats:p>Recording cellular events could advance our understanding of cellular history and responses to stimuli. The construction of intracellular memory devices, however, is challenging. Tang and Liu used Cas9 nucleases and base editors to record amplitude, duration, and order of stimuli as stable changes in both genomic and extrachromosomal DNA content (see the Perspective by Ho and Bennett). The recording of multiple stimuli—including exposure to antibiotics, nutrients, viruses, and light, as well as Wnt signaling—was achieved in living bacterial and human cells. Recorded memories could be erased and re-recorded over multiple cycles.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aap8992">eaap8992</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6385" page="150" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat3236">150</jats:related-article> </jats:p>

<jats:p>Transparency is critical when it comes to decision-making that broadly affects the public, particularly when it comes to policies purported to be grounded in scientific evidence. The scientific community has been increasingly focused on improving the transparency of research through initiatives that represent good-faith efforts to enhance the robustness of scientific findings and to increase access to and utility of data that underlie research. Yet, concerns about transparency associated with scientific results continue to emerge in political discussions. Most recently in the United States, a new proposal by the Environmental Protection Agency (EPA) would eliminate the use of publications in its policy discussions for which all underlying data are not publicly available. Here, a push for transparency appears actually to be a mechanism for suppressing important scientific evidence in policy-making, thereby threatening the public's well-being.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>