Catálogo de publicaciones - revistas

<jats:title>Benign colonization of the gut</jats:title> <jats:p> Microbial communities in the gut can be highly individual. What engenders this specificity? The gut characteristically produces gram quantities of immunoglobulin A (IgA) antibody, which is presumed to protect the gut from pathogen attack. Donaldson <jats:italic>et al.</jats:italic> engineered strains of <jats:italic>Bacteroides fragilis</jats:italic> , a common human commensal, to modify its surface capsule, which affects its ability to colonize the germ-free mouse gut. Capsule changes altered the capacity of IgA to bind to the different mutants. It seems that this commensal species exploits IgA sticking power specifically to give it a competitive edge and to promote its establishment in the gut. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6390" page="795" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aaq0926">795</jats:related-article> </jats:p>

<jats:title>Profiling transcription—a SLAM dunk</jats:title> <jats:p> Identification of the direct target genes of transcription factors could shed light on how healthy cells become malignant. Muhar <jats:italic>et al.</jats:italic> applied a modified version of a transcript-mapping method called SLAM-seq to identify the target genes of two transcriptional regulators of major interest in cancer research (see the Perspective by Sabò and Amati). The MYC oncoprotein selectively activates transcription of just a few genes, primarily those involved in basic cell metabolism. In contrast, BRD4, a bromodomain-containing protein that is being targeted for cancer therapy, activates transcription of many genes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6390" page="800" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aao2793">800</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6390" page="713" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat6664">713</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>