Catálogo de publicaciones - revistas

<jats:title>Building smarter synthetic biological circuits</jats:title> <jats:p> Synthetic genetic and biological regulatory circuits can enable logic functions to form the basis of biological computing; synthetic biology can also be used to control cell behaviors (see the Perspective by Glass and Alon). Andrews <jats:italic>et al.</jats:italic> used mathematical models and computer algorithms to combine standardized components and build programmable genetic sequential logic circuits. Such circuits can perform regulatory functions much like the biological checkpoint circuits of living cells. Circuits composed of interacting proteins could be used to bypass gene regulation, interfacing directly with cellular pathways without genome modification. Gao <jats:italic>et al.</jats:italic> engineered proteases that regulate one another, respond to diverse inputs that include oncogene activation, process signals, and conditionally activate responses such as those leading to cell death. This platform should facilitate development of “smart” therapeutic circuits for future biomedical applications. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aap8987">eaap8987</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6408" page="1252" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat5062">1252</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6408" page="1199" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aav2497">1199</jats:related-article> </jats:p>

<jats:title>Interspecies competition shapes communities</jats:title> <jats:p>The gut microbiota of mammals is diverse and dynamic, and gut bacteria respond sensitively to diet and drug intake. Nevertheless, in a healthy adult, microbial community composition remains remarkably stable over time, despite being highly individual. García-Bayona and Comstock review the mechanisms that gut bacterial species use to jostle for space and resources and maintain their populations in the face of intense and varied competition. Bacteria have evolved a range of antibiotics, bacteriocins, toxins, and delivery devices to enable interspecies conflict. These interbacterial weapons possess a spectrum of specificities and range from those that target strains of their own species to broad-acting bacteriocides. This toxic armamentarium provides a valuable resource for potential therapeutic development.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat2456">eaat2456</jats:related-article> </jats:p>

<jats:title>Dissecting the gut-brain axis</jats:title> <jats:p> It is generally believed that cells in the gut transduce sensory information through the paracrine action of hormones. Kaelberer <jats:italic>et al.</jats:italic> found that, in addition to the well-described classical paracrine transduction, enteroendocrine cells also form fast, excitatory synapses with vagal afferents (see the Perspective by Hoffman and Lumpkin). This more direct circuit for gut-brain signaling uses glutamate as a neurotransmitter. Thus, sensory cues that stimulate the gut could potentially be manipulated to influence specific brain functions and behavior, including those linked to food choices. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat5236">eaat5236</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6408" page="1203" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aau9973">1203</jats:related-article> </jats:p>