Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Pontus Orning
; Dan Weng; Kristian Starheim; Dmitry Ratner; Zachary Best; Bettina Lee; Alexandria Brooks; Shiyu Xia; Hao Wu; Michelle A. Kelliher; Scott B. Berger; Peter J. Gough; John Bertin; Megan M. Proulx; Jon D. Goguen; Nobuhiko Kayagaki; Katherine A. Fitzgerald; Egil Lien
<jats:p>Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome-activated caspase-1 or -11. It is currently unknown whether macrophage GSDMD can be processed by other mechanisms. Here, we describe an additional pathway controlling GSDMD processing. The inhibition of TAK1 or IκB kinase (IKK) by the <jats:italic>Yersinia</jats:italic> effector protein YopJ elicits RIPK1- and caspase-8–dependent cleavage of GSDMD, which subsequently results in cell death. GSDMD processing also contributes to the NLRP3 inflammasome–dependent release of interleukin-1β (IL-1β). Thus, caspase-8 acts as a regulator of GSDMD-driven cell death. Furthermore, this study establishes the importance of TAK1 and IKK activity in the control of GSDMD cleavage and cytotoxicity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1064-1069
At the end of the road, a new start
Francis Aguisanda
Palabras clave: Multidisciplinary.
Pp. 1078-1078
Trump emphasizes workforce training in new vision for STEM education
Jeffrey Mervis
Palabras clave: Multidisciplinary.
Pp. No disponible
Did our ancient sun go on a diet? Bands of martian rock could solve the ‘faint young sun’ paradox
Joshua Sokol
Palabras clave: Multidisciplinary.
Pp. No disponible
Reorganization sparks turmoil at Copenhagen’s research powerhouse museum
Gretchen Vogel
Palabras clave: Multidisciplinary.
Pp. No disponible
Cosmic cacophony of colliding black holes continues
Adrian Cho
Palabras clave: Multidisciplinary.
Pp. No disponible
This famous tortoise lived for 100 years. His genome may reveal how he did it
Mitch Leslie
Palabras clave: Multidisciplinary.
Pp. No disponible
Four small cities may have played an outsize role in spreading deadly flu
Erin I. Garcia de Jesus
Palabras clave: Multidisciplinary.
Pp. No disponible
Trump ocean plan axes climate chapter
Christa Marshall
Palabras clave: Multidisciplinary.
Pp. No disponible