Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein
Amer Alam
; Julia Kowal; Eugenia Broude; Igor Roninson; Kaspar P. Locher
<jats:title>To transport or not to transport</jats:title> <jats:p> Therapeutic drug delivery into cells is complicated by membrane proteins like ABCB1 (also termed P-glycoprotein) that shuttle diverse compounds out of cells. Alam <jats:italic>et al.</jats:italic> determined high-resolution cryo–electron microscopy structures of ABCB1 bound either to a substrate, the cancer drug Taxol, or to the ABCB1 inhibitor zosuquidar. The conformational changes that facilitate drug transport are caused by hydrolysis of adenosine triphosphate (ATP). The structures show that, although Taxol and zosquidar bind to the same site, subtle structural differences lead to altered conformations of the nucleotide binding domains that are responsible for ATP hydrolysis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6428" page="753" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aav7102">753</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 753-756
Gordon Research Conferences
<jats:p> The 2019 Gordon Research Conference schedule was published on pages 758 to 781 of this issue of the print version of <jats:italic>Science</jats:italic> . The current schedule can also be found online at <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.grc.org/">www.grc.org/</jats:ext-link> . </jats:p>
Palabras clave: Multidisciplinary.
Pp. 758-781
New Products
<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 782-782
Waiting for reimbursement
Jessica E. Sagers
Palabras clave: Multidisciplinary.
Pp. 786-786
New app reveals the hidden landscapes within Georgia O’Keeffe’s paintings
Sid Perkins
Palabras clave: Multidisciplinary.
Pp. No disponible
How secret, late-night experiments transformed two scientists into master cartoonists
Alex Fox
Palabras clave: Multidisciplinary.
Pp. No disponible
Why sparks fly when you microwave grapes
Alex Fox
Palabras clave: Multidisciplinary.
Pp. No disponible
Ancient humans hunted monkeys for tens of thousands of years
Virginia Morell
Palabras clave: Multidisciplinary.
Pp. No disponible
Ultraviolet light could provide a powerful new source of green fuel
Robert Service
Palabras clave: Multidisciplinary.
Pp. No disponible
Researchers spy signs of slavery from space
Sarah Scoles
Palabras clave: Multidisciplinary.
Pp. No disponible