Catálogo de publicaciones - revistas

<jats:title>Structures of the simplest replisome</jats:title> <jats:p> The DNA replisome performs concerted parental-strand separation and DNA synthesis on both strands. Gao <jats:italic>et al.</jats:italic> report the cryo–electron microscopy structures of the minimum set of bacteriophage T7 proteins that can carry out leading- and lagging-strand synthesis at the replication fork (see the Perspective by Li and O'Donnell). Three key enzymes involved in DNA replication—DNA polymerase, helicase, and primase—were visualized in complex with substrate DNA, demonstrating their highly dynamic organizations on both strands. Comparison of prokaryotic and eukaryotic replisomes reveals evolutionarily conserved operating principles and provides a structural basis for understanding coordination among DNA replication, recombination, and repair. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav7003">eaav7003</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6429" page="814" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw6265">814</jats:related-article> </jats:p>

<jats:title>Coincidence detection in synaptogenesis</jats:title> <jats:p> In the brain, synaptic connections are formed with exquisite specificity, but the underlying molecular mechanisms remain largely unexplored. Synapse formation is thought to involve bidirectional signaling by proteins that bind to each other across the synaptic cleft. Sando <jats:italic>et al.</jats:italic> used conditional genetic tools and in vitro assays to investigate the mechanisms of synapse formation. They found that synapse formation in the mouse hippocampus requires latrophilins. Latrophilins are G protein–coupled receptors that bind to cell-surface proteins called teneurins and fibronectin leucine-rich repeat transmembrane proteins (FLRTs). Two different latrophilins mediated formation of distinct synapses on the same hippocampal neuron. This function required binding of both teneurins and FLRTs. Thus, latrophilins may guide synapse formation by coincidence signaling, which could help to explain the specificity of synaptic connections. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav7969">eaav7969</jats:related-article> </jats:p>

<jats:p>Last week, the Centers for Disease Control and Prevention announced that more than 100 cases of measles, spanning 10 states, had been reported in the United States since the beginning of the year. This news came on the heels of the World Health Organization's estimate of over 200,000 cases of measles in 2018. These numbers signal the reemergence of a preventable, deadly disease, attributed in significant part to vaccine hesitancy. Communities and nations must seriously consider leveraging the law to protect against the spread of this highly contagious disease.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>In first public remarks, Kelvin Droegemeier calls partnerships key to research preeminence.</jats:p>

<jats:p>Experiments show how chaos defeats computer models.</jats:p>

<jats:p>Data protection measure may block reuse of data in biobanks.</jats:p>

<jats:p>Mission to seek clues to the big bang and capture the combined glow of all galaxies.</jats:p>

<jats:p>A surge in satellite data and artificial intelligence helps guide enforcement on the ground.</jats:p>

<jats:p>HIV drug targets a protein that may hinder the brain's regrowth after damage.</jats:p>