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No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

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doi: 10.1126/science.aav1444

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Pau Castel; Alice Cheng; Antonio Cuevas-Navarro; David B. Everman; Alex G. Papageorge; Dhirendra K. Simanshu; Alexandra Tankka; Jacqueline Galeas; Anatoly Urisman; Frank McCormick

<jats:title>Defective degradation as disease mechanism</jats:title> <jats:p> Ubiquitination often targets proteins for destruction. Castel <jats:italic>et al.</jats:italic> describe a mechanism by which mutations in the small guanine triphosphatase RIT1 may act to cause certain developmental disorders and cancers. They detected a protein, LZTR1, that interacted with wild-type RIT1 but not with oncogenic mutant forms of RIT1. LZTR1 acts as a substrate-specific adaptor for a ubiquitin ligase. Altered forms of RIT1 that are not subject to ubiquitin-mediated degradation thus accumulate. Because RIT1 functions in growth factor signaling and excessive signaling, these findings may explain the malignancies associated with RIT1 mutations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6432" page="1226" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aav1444">1226</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1226-1230

doi: 10.1126/science.aav4040

The genomic history of the Iberian Peninsula over the past 8000 years

Iñigo Olalde; Swapan Mallick; Nick Patterson; Nadin Rohland; Vanessa Villalba-Mouco; Marina Silva; Katharina Dulias; Ceiridwen J. Edwards; Francesca Gandini; Maria Pala; Pedro Soares; Manuel Ferrando-Bernal; Nicole Adamski; Nasreen Broomandkhoshbacht; Olivia Cheronet; Brendan J. Culleton; Daniel Fernandes; Ann Marie Lawson; Matthew Mah; Jonas Oppenheimer; Kristin Stewardson; Zhao Zhang; Juan Manuel Jiménez Arenas; Isidro Jorge Toro Moyano; Domingo C. Salazar-García; Pere Castanyer; Marta Santos; Joaquim Tremoleda; Marina Lozano; Pablo García Borja; Javier Fernández-Eraso; José Antonio Mujika-Alustiza; Cecilio Barroso; Francisco J. Bermúdez; Enrique Viguera Mínguez; Josep Burch; Neus Coromina; David Vivó; Artur Cebrià; Josep Maria Fullola; Oreto García-Puchol; Juan Ignacio Morales; F. Xavier Oms; Tona Majó; Josep Maria Vergès; Antònia Díaz-Carvajal; Imma Ollich-Castanyer; F. Javier López-Cachero; Ana Maria Silva; Carmen Alonso-Fernández; Germán Delibes de Castro; Javier Jiménez Echevarría; Adolfo Moreno-Márquez; Guillermo Pascual Berlanga; Pablo Ramos-García; José Ramos-Muñoz; Eduardo Vijande Vila; Gustau Aguilella Arzo; Ángel Esparza Arroyo; Katina T. Lillios; Jennifer Mack; Javier Velasco-Vázquez; Anna Waterman; Luis Benítez de Lugo Enrich; María Benito Sánchez; Bibiana Agustí; Ferran Codina; Gabriel de Prado; Almudena Estalrrich; Álvaro Fernández Flores; Clive Finlayson; Geraldine Finlayson; Stewart Finlayson; Francisco Giles-Guzmán; Antonio Rosas; Virginia Barciela González; Gabriel García Atiénzar; Mauro S. Hernández Pérez; Armando Llanos; Yolanda Carrión Marco; Isabel Collado Beneyto; David López-Serrano; Mario Sanz Tormo; António C. Valera; Concepción Blasco; Corina Liesau; Patricia Ríos; Joan Daura; María Jesús de Pedro Michó; Agustín A. Diez-Castillo; Raúl Flores Fernández; Joan Francès Farré; Rafael Garrido-Pena; Victor S. Gonçalves; Elisa Guerra-Doce; Ana Mercedes Herrero-Corral; Joaquim Juan-Cabanilles; Daniel López-Reyes; Sarah B. McClure; Marta Merino Pérez; Arturo Oliver Foix; Montserrat Sanz Borràs; Ana Catarina Sousa; Julio Manuel Vidal Encinas; Douglas J. Kennett; Martin B. Richards; Kurt Werner Alt; Wolfgang Haak; Ron Pinhasi; Carles Lalueza-Fox; David Reich

<jats:title>Genomics of the Iberian Peninsula</jats:title> <jats:p> Ancient DNA studies have begun to help us understand the genetic history and movements of people across the globe. Focusing on the Iberian Peninsula, Olalde <jats:italic>et al.</jats:italic> report genome-wide data from 271 ancient individuals from Iberia (see the Perspective by Vander Linden). The findings provide a comprehensive genetic time transect of the region. Linguistics analysis and genetic analysis of archaeological human remains dating from about 7000 years ago to the present elucidate the genetic impact of prehistoric and historic migrations from Europe and North Africa. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6432" page="1230" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aav4040">1230</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6432" page="1153" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw8020">1153</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1230-1234

doi: 10.1126/science.363.6432.1236

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1236-1236

doi: 10.1126/science.363.6432.1246