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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Physicists predict a way to squeeze light from the vacuum of empty space
Adrian Cho
Palabras clave: Multidisciplinary.
Pp. No disponible
Ever dream of controlling robot swarms? This new virtual reality headset could help
Edd Gent
Palabras clave: Multidisciplinary.
Pp. No disponible
Watch this kangaroo rat kick a rattlesnake in the face
Elizabeth Pennisi
Palabras clave: Multidisciplinary.
Pp. No disponible
Top stories: The true cost of cash bail, tuft cells, and a fossil-saving Australian farmer
Alex Fox
Palabras clave: Multidisciplinary.
Pp. No disponible
EPA panel seeks to bring back fired scientists for clean-air review
Sean Reilly
Palabras clave: Multidisciplinary.
Pp. No disponible
Our mysterious cousins—the Denisovans—may have mated with modern humans as recently as 15,000 years ago
Ann Gibbons
Palabras clave: Multidisciplinary.
Pp. No disponible
Could computers provide short-term warnings of the world’s worst floods?
Jeffrey Brainard
Palabras clave: Multidisciplinary.
Pp. No disponible
Last-minute deal grants European money to U.K.-based fusion reactor
Daniel Clery
Palabras clave: Multidisciplinary.
Pp. No disponible
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
Johanna M. Sweere
; Jonas D. Van Belleghem; Heather Ishak; Michelle S. Bach; Medeea Popescu; Vivekananda Sunkari; Gernot Kaber; Robert Manasherob; Gina A. Suh; Xiou Cao; Christiaan R. de Vries; Dung N. Lam; Payton L. Marshall; Maria Birukova; Ethan Katznelson; Daniel V. Lazzareschi; Swathi Balaji; Sundeep G. Keswani; Thomas R. Hawn; Patrick R. Secor; Paul L. Bollyky
<jats:title>Phage subverts immune response</jats:title> <jats:p> <jats:italic>Pseudomonas aeruginosa</jats:italic> ( <jats:italic>Pa</jats:italic> ) is a multidrug-resistant Gramnegative bacterium commonly found in health care settings. <jats:italic>Pa</jats:italic> infections frequently result in considerable morbidity and mortality. Sweere <jats:italic>et al.</jats:italic> found that a type of temperate filamentous bacteriophage that infects and integrates into <jats:italic>Pa</jats:italic> is associated with chronic human wound infections. Likewise, wounds in mice colonized with phage-infected <jats:italic>Pa</jats:italic> were more severe and longer-lasting than those colonized by <jats:italic>Pa</jats:italic> alone. Immune cell uptake of phage-infected <jats:italic>Pa</jats:italic> resulted in phage RNA production and inappropriate antiviral immune responses, impeding bacterial clearance. Both phage vaccination and transfer of antiphage antibodies were protective against <jats:italic>Pa</jats:italic> infection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat9691">eaat9691</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
T cell stemness and dysfunction in tumors are triggered by a common mechanism
Suman Kumar Vodnala; Robert Eil; Rigel J. Kishton; Madhusudhanan Sukumar; Tori N. Yamamoto; Ngoc-Han Ha; Ping-Hsien Lee; MinHwa Shin; Shashank J. Patel; Zhiya Yu; Douglas C. Palmer; Michael J. Kruhlak; Xiaojing Liu; Jason W. Locasale; Jing Huang; Rahul Roychoudhuri; Toren Finkel; Christopher A. Klebanoff; Nicholas P. Restifo
<jats:title>Stemness against adversity</jats:title> <jats:p> T lymphocytes are powerful immune cells that can destroy tumors, but cancers have developed tricks to evade killing. Vodnala <jats:italic>et al.</jats:italic> found that potassium ions in the tumor microenvironment serve a dual role of influencing T cell effector function and stemness (see the Perspective by Baixauli Celda <jats:italic>et al.</jats:italic> ). Increased potassium impairs T cell metabolism and nutrient uptake, resulting in a starvation state known as autophagy. The increased potassium can also preserve T cells in a stem-like state where they retain the capacity to divide. These seemingly divergent processes are linked to the cellular distribution of acetyl–coenzyme A, which, when manipulated, can restore the ability of human T cells to eliminate tumors in mice. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau0135">eaau0135</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6434" page="1395" related-article-type="in-this-issue" vol="363" xlink:href="10.1126/science.aaw8800">1395</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible