Catálogo de publicaciones - revistas

<jats:p> Ota <jats:italic>et al</jats:italic> . (Reports, 15 June 2018, p. 1246) report using pseudo-random optical masks and a spatial-temporal transformation to perform blur-free, high–frame rate imaging of cells in flow with a high signal-to-noise ratio. They also claim sorting at rates of 3000 cells per second, based on imaging data. The experiments conducted and results reported in their study are insufficient to support these conclusions. </jats:p>

<jats:title>Neuron activity across the brain</jats:title> <jats:p> How is it that groups of neurons dispersed through the brain interact to generate complex behaviors? Three papers in this issue present brain-scale studies of neuronal activity and dynamics (see the Perspective by Huk and Hart). Allen <jats:italic>et al.</jats:italic> found that in thirsty mice, there is widespread neural activity related to stimuli that elicit licking and drinking. Individual neurons encoded task-specific responses, but every brain area contained neurons with different types of response. Optogenetic stimulation of thirst-sensing neurons in one area of the brain reinstated drinking and neuronal activity across the brain that previously signaled thirst. Gründemann <jats:italic>et al.</jats:italic> investigated the activity of mouse basal amygdala neurons in relation to behavior during different tasks. Two ensembles of neurons showed orthogonal activity during exploratory and nonexploratory behaviors, possibly reflecting different levels of anxiety experienced in these areas. Stringer <jats:italic>et al.</jats:italic> analyzed spontaneous neuronal firing, finding that neurons in the primary visual cortex encoded both visual information and motor activity related to facial movements. The variability of neuronal responses to visual stimuli in the primary visual area is mainly related to arousal and reflects the encoding of latent behavioral states. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6437" page="eaav3932" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aav3932">eaav3932</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6437" page="eaav8736" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aav8736">eaav8736</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6437" page="eaav7893" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aav7893">eaav7893</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6437" page="236" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax1512">236</jats:related-article> </jats:p>