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Science

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

Long-term functional maintenance of primary human hepatocytes in vitro

Chengang XiangORCID; Yuanyuan DuORCID; Gaofan MengORCID; Liew Soon Yi; Shicheng Sun; Nan Song; Xiaonan ZhangORCID; Yiwei XiaoORCID; Jie Wang; Zhigang Yi; Yifang Liu; Bingqing XieORCID; Min Wu; Jun Shu; Da Sun; Jun Jia; Zhen Liang; Dong Sun; Yanxiang Huang; Yan ShiORCID; Jun Xu; Fengmin Lu; Cheng Li; Kuanhui Xiang; Zhenghong Yuan; Shichun LuORCID; Hongkui DengORCID

<jats:title>Keep hepatocytes fresh</jats:title> <jats:p> Freshly isolated primary human hepatocytes (PHHs) quickly lose their identity and function in vitro, limiting their application in modeling infectious liver diseases and screening drugs. Xiang <jats:italic>et al.</jats:italic> describe a simple and effective five-chemical culture condition that can maintain the mature function of cultured PHHs for an extended period of time. PHHs cultured in this way can support the entire viral life cycle and recapitulate long-term infection of the hepatitis B virus. This system created a useful drug-screening platform for developing new antiviral strategies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6438" page="399" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aau7307">399</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 399-402

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 403-403

A cure for burnout

Nikole D. Patson

Palabras clave: Multidisciplinary.

Pp. 406-406

House panel proposes $2 billion increase for NIH

Jocelyn Kaiser

Palabras clave: Multidisciplinary.

Pp. No disponible

Report: NIH bars physicians who criticized sepsis trial from speaking with investigators

Jennifer Couzin-Frankel

Palabras clave: Multidisciplinary.

Pp. No disponible

Want to become a better mentor? Ask for anonymous feedback

Katie Langin

Palabras clave: Multidisciplinary.

Pp. No disponible

Hitchhiking bacteria might help their host navigate via magnetic fields

Helen Santoro

Palabras clave: Multidisciplinary.

Pp. No disponible

Sudanese geneticist released from prison after revolution: ‘I’m very optimistic’

Linda Nordling

Palabras clave: Multidisciplinary.

Pp. No disponible

Thousands of scientists in Argentina strike to protest budget cuts

Lindzi Wessel

Palabras clave: Multidisciplinary.

Pp. No disponible

In lopsided vote, U.S. science academy backs move to eject sexual harassers

Meredith Wadman

Palabras clave: Multidisciplinary.

Pp. No disponible