Catálogo de publicaciones - revistas

<jats:title>The path to elimination</jats:title> <jats:p> Measles is highly infectious and can be dangerous. The classic 1968 vaccine is highly effective, and it should be possible to eliminate measles. Graham <jats:italic>et al.</jats:italic> found that measles transmission changes as vaccination coverage and birth rates (that is, the rate of arrival of susceptible individuals into the population) change in a country in response to socioeconomic variables. As a result, measles everywhere follows the canonical mode of decline in response to vaccination campaigns. Incidence is initially high, and variability is low. As incidence declines, variability increases, and as incidence drops toward elimination, so does variability. It is possible to identify countries that are deviating from this expectation and to adapt their vaccination programs to regain the path to elimination. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6440" page="584" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aau6299">584</jats:related-article> </jats:p>

<jats:title>Fish catch color with rods</jats:title> <jats:p> Vertebrates are typically thought to have a consistent system for processing light, in which multiple cone opsins permit color vision during the day, but a single rod opsin provides only monochrome vision in the dark. Musilova <jats:italic>et al.</jats:italic> analyzed more than 100 deep-sea fish genomes and found a previously unknown proliferation of rod opsin genes that generate rod opsin photopigments that are tuned to different wavelengths of light. These receptors may allow the fish to perceive bioluminescent signals that pervade their deep-sea environment. These results reveal a previously undescribed visual system that allows for color vision in the dark. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6440" page="588" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aav4632">588</jats:related-article> </jats:p>

<jats:title>Cooperativity in synthetic gene circuits</jats:title> <jats:p> Synthetic biologists would like to be able to make gene regulatory circuits that mimic key properties of eukaryotic gene regulation. Taking a cue from multimeric transcription factor complexes, Bashor <jats:italic>et al.</jats:italic> developed synthetic transcriptional circuits that produce nonlinear behavior from cooperativity (see the Perspective by Ng and El-Samad). Their system uses clamp proteins with multiple protein-interaction domains. Circuit behavior can be tuned by altering the number or affinities of the interactions according to a mathematical model. The authors created synthetic circuits with desired functions common in biology, for example, switch-like behavior or Boolean decision functions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6440" page="593" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aau8287">593</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6440" page="531" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax4556">531</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>