Catálogo de publicaciones - revistas

<jats:title>Dynamic metasurfaces</jats:title> <jats:p> Optical metasurfaces have opened an entirely new field in the quest to manipulate light. Optical metasurfaces can locally impart changes to the amplitude, phase, and polarization of propagating waves. To date, most of these metasurfaces have been passive, with the optical properties largely set in the fabrication process. Shaltout <jats:italic>et al.</jats:italic> review recent developments toward time-varying metasurfaces and explore the opportunities that adding dynamic control can offer in terms of actively controlling the flow of light. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat3100">eaat3100</jats:related-article> </jats:p>

<jats:title>Supporting tumor suppression</jats:title> <jats:p> The protein PTEN is a phosphatase and tumor suppressor whose activity is often decreased in human cancers. Thus, reactivating such a protein could potentially be an effective therapy against cancer. Lee <jats:italic>et al.</jats:italic> identified a ubiquitin E3 ligase (WWP1) as a PTEN-interacting protein that modifies PTEN and inhibits its tumor suppressive activity (see the Perspective by Parsons). Depletion of WWP1 increased dimerization and membrane recruitment of PTEN. A natural compound found to be a pharmacological inhibitor of WWP1 inhibited tumor growth in a mouse model of prostate cancer. Thus, reactivation of the tumor suppressor PTEN may provide a strategy for battling tumors. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aau0159">eaau0159</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6441" page="633" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax5526">633</jats:related-article> </jats:p>

<jats:p>Last month, the House Appropriations Committee of the U.S. Congress began drafting its Fiscal Year 2020 funding bill. Among the promising news is the committee's support for a $2 billion increase above Fiscal Year 2019 for the U.S. National Institutes of Health (NIH), the first step in what is likely to be a long and contentious budget process. Why, then, is the cycle of success that the U.S. scientific enterprise has enjoyed since the mid-20th century in jeopardy?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>For second winter in a row, ice cover shrinks to lowest levels seen in at least 4 decades.</jats:p>