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<jats:title>Nutritional interdependencies</jats:title> <jats:p> Bacteria and archaea show a wide range of nutritional specialism. Not every organism can synthesize essential components and may need to trade for them. Taking as an example a diverse and interesting family of enzyme cofactors—the cobalt-containing cobamides, which include vitamin B <jats:sub>12</jats:sub> —Sokolovskaya <jats:italic>et al.</jats:italic> reviewed the interdependencies among microorganisms for this suite of nutrients. Cobamides are required for many processes, from catabolism of carbon sources to nucleotide biosynthesis, and are needed by a majority of microbes, from those in the gut to those in the oceans. Availability of cobamides is patchy and habitat specific, and nonspecific scavenging may not be adequate to obtain a specific cobamide structure required by an organism. Therefore, a variety of mutualisms have evolved to deliver and import specific structural variants of cobamides between organisms or among consortia of eukaryotes and prokaryotes by an equal variety of subtle and distinct mechanisms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6499" page="48" related-article-type="in-this-issue" vol="369">48</jats:related-article> </jats:p>

<jats:title>A real-time trial of a cancer blood test</jats:title> <jats:p> Cancers diagnosed early are often more responsive to treatment. Blood tests that detect molecular markers of cancer have successfully identified individuals already known to have the disease. Lennon <jats:italic>et al.</jats:italic> conducted an exploratory study that more closely reflects the way in which such blood tests would be used in the future. They evaluated the feasibility and safety of incorporating a multicancer blood test into the routine clinical care of 10,000 women with no history of cancer. Over a 12-month period, the blood test detected 26 cancers of different types. A combination of the blood test and positron emission tomography–computed tomography (PET-CT) imaging led to surgical removal of nine of these cancers. Use of the blood test did not result in a large number of futile follow-up procedures. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6499" page="eabb9601" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abb9601">eabb9601</jats:related-article> </jats:p>

<jats:p>As a psychological scientist who investigates how individuals and communities respond to collective traumas, I study human resilience in a range of situations—from earthquakes and hurricanes to mass violence and war. Shortly after the 11 September 2001 terrorist attacks against the United States, I sat in the White House Office of Homeland Security discussing community resilience. Although the threat to society seemed real and continuing, national leaders were anxious to get people back on airplanes and into high-rise office buildings. In retrospect, the nation proved to be quite resilient: The threat of terrorism was never eliminated, but industries and urban centers continued to thrive. Decades later, the United States and world face another threat, equally amorphous and extremely deadly. In months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has infected over 10 million people, killed over 125,000 Americans, and led to more than 500,000 deaths worldwide. A vaccine for COVID-19 is perhaps a year away. What does psychological science tell us about how individuals are responding—and will respond—as the pandemic waxes and wanes? What will the postpandemic “normal” look like? Will our society prove to be resilient?</jats:p>