Catálogo de publicaciones - revistas

<jats:title>Insights from big data</jats:title> <jats:p>The billions of neurons that make up the adult brain are organized into domains and circuits during development. High-resolution measurements such as those enabled by single-cell molecular profiling have revealed unexpected cellular diversity. Genomic tools are lending insight into mechanisms behind neurodevelopmental disorders. Briscoe and Marèn review the insights gained as big data analyses are applied to neurodevelopmental questions.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaz8627">eaaz8627</jats:related-article> </jats:p>

<jats:title>The MTOC is “speck”-tacular</jats:title> <jats:p> Inflammasome complexes are formed in response to pathogen-associated molecules. They initiate both the maturation of inflammatory cytokines and pyroptosis, a type of programmed cell death. One notable feature for inflammasome activation is the formation of a single supramolecular punctum (or “speck”) in each affected cell. However, the location and mechanism of speck formation is poorly understood. Magupalli <jats:italic>et al.</jats:italic> report that for NLRP3- and pyrin-mediated inflammasomes, their assembly and downstream functions occur at the microtubule-organizing center (MTOC). This process requires the dynein adaptor HDAC6, which is also a central player in aggresome formation and autophagosomal degradation at the MTOC. This work links several important cellular processes and provides clues for how inflammasomes are efficiently regulated. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aas8995">eaas8995</jats:related-article> </jats:p>

<jats:title>Imprints of racism</jats:title> <jats:p> Cities create challenging environments for many nonhuman species, and the presence of nonhumans in cities influences the health and well-being of the humans with which they share the environment. Distinct urban conditions are created by landscape modification, but the history of this transformation is not equal across urban environments. Schell <jats:italic>et al.</jats:italic> review how systematic racist practices such as residential segregation, enacted in part through redlining, have led to an unequal distribution of “nature” within cities. These inequities continue to play out in both the ecological processes of cities and the welfare of their residents. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aay4497">eaay4497</jats:related-article> </jats:p>

<jats:p> When President Donald Trump began talking to the public about coronavirus disease 2019 (COVID-19) in February and March, scientists were stunned at his seeming lack of understanding of the threat. We assumed that he either refused to listen to the White House briefings that must have been occurring or that he was being deliberately sheltered from information to create plausible deniability for federal inaction. Now, because famed <jats:italic>Washington Post</jats:italic> journalist Bob Woodward recorded him, we can hear Trump's own voice saying that he understood precisely that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was deadly and spread through the air. As he was playing down the virus to the public, Trump was not confused or inadequately briefed: He flat-out lied, repeatedly, about science to the American people. These lies demoralized the scientific community and cost countless lives in the United States. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>New research focuses on the health and public safety impacts of "decarceration."</jats:p>

<jats:p>Researchers are hunting for myocarditis in COVID-19 survivors.</jats:p>

<jats:p>Patients report benefits, but how near-infrared protects brain cells is unclear, and some scientists are skeptical.</jats:p>

<jats:p>Massive sequencing effort shows people of diverse genetic backgrounds adopted Viking culture.</jats:p>

<jats:p>New report finds glimmers of progress, but nations are not achieving targets.</jats:p>