Catálogo de publicaciones - revistas
Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme
Shoucai Ma
; Dmitry Lapin; Li Liu; Yue Sun; Wen Song; Xiaoxiao Zhang; Elke Logemann; Dongli Yu; Jia Wang; Jan Jirschitzka; Zhifu Han; Paul Schulze-Lefert; Jane E. Parker; Jijie Chai
<jats:title>Tetrameric immune receptors</jats:title> <jats:p> Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (TIR) domains (TIR-NLRs) (see the Perspective by Tian and Li). Ma <jats:italic>et al.</jats:italic> studied the <jats:italic>Arabidopsis thaliana</jats:italic> TIR-NLR RPP1 (recognition of <jats:italic>Peronospora parasitica</jats:italic> 1) and its response to effectors from an oomycete pathogen. Martin <jats:italic>et al.</jats:italic> studied the <jats:italic>Nicotiana benthamiana</jats:italic> TIR-NLR ROQ1 (recognition of XopQ 1) and its response to the <jats:italic>Xanthomonas</jats:italic> effector. Both groups found that these TIR-NLRs formed tetramers that, when activated by binding to the pathogen effector, exposed the active site of a nicotinamide adenine dinucleoside (NAD) hydrolase. Thus, recognition of the pathogen effector initiates NAD hydrolysis and begins the immune response. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe3069">eabe3069</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd9993">eabd9993</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6521" page="1163" related-article-type="in-this-issue" vol="370" xlink:href="10.1126/science.abf2833">1163</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
David E. Gordon; Joseph Hiatt; Mehdi Bouhaddou; Veronica V. Rezelj; Svenja Ulferts; Hannes Braberg; Alexander S. Jureka; Kirsten Obernier; Jeffrey Z. Guo; Jyoti Batra; Robyn M. Kaake; Andrew R. Weckstein; Tristan W. Owens; Meghna Gupta; Sergei Pourmal; Erron W. Titus; Merve Cakir; Margaret Soucheray; Michael McGregor; Zeynep Cakir; Gwendolyn Jang; Matthew J. O’Meara; Tia A. Tummino; Ziyang Zhang; Helene Foussard; Ajda Rojc; Yuan Zhou; Dmitry Kuchenov; Ruth Hüttenhain; Jiewei Xu; Manon Eckhardt; Danielle L. Swaney; Jacqueline M. Fabius; Manisha Ummadi; Beril Tutuncuoglu; Ujjwal Rathore; Maya Modak; Paige Haas; Kelsey M. Haas; Zun Zar Chi Naing; Ernst H. Pulido; Ying Shi; Inigo Barrio-Hernandez; Danish Memon; Eirini Petsalaki; Alistair Dunham; Miguel Correa Marrero; David Burke; Cassandra Koh; Thomas Vallet; Jesus A. Silvas; Caleigh M. Azumaya; Christian Billesbølle; Axel F. Brilot; Melody G. Campbell; Amy Diallo; Miles Sasha Dickinson; Devan Diwanji; Nadia Herrera; Nick Hoppe; Huong T. Kratochvil; Yanxin Liu; Gregory E. Merz; Michelle Moritz; Henry C. Nguyen; Carlos Nowotny; Cristina Puchades; Alexandrea N. Rizo; Ursula Schulze-Gahmen; Amber M. Smith; Ming Sun; Iris D. Young; Jianhua Zhao; Daniel Asarnow; Justin Biel; Alisa Bowen; Julian R. Braxton; Jen Chen; Cynthia M. Chio; Un Seng Chio; Ishan Deshpande; Loan Doan; Bryan Faust; Sebastian Flores; Mingliang Jin; Kate Kim; Victor L. Lam; Fei Li; Junrui Li; Yen-Li Li; Yang Li; Xi Liu; Megan Lo; Kyle E. Lopez; Arthur A. Melo; Frank R. Moss; Phuong Nguyen; Joana Paulino; Komal Ishwar Pawar; Jessica K. Peters; Thomas H. Pospiech; Maliheh Safari; Smriti Sangwan; Kaitlin Schaefer; Paul V. Thomas; Aye C. Thwin; Raphael Trenker; Eric Tse; Tsz Kin Martin Tsui; Feng Wang; Natalie Whitis; Zanlin Yu; Kaihua Zhang; Yang Zhang; Fengbo Zhou; Daniel Saltzberg; Anthony J. Hodder; Amber S. Shun-Shion; Daniel M. Williams; Kris M. White; Romel Rosales; Thomas Kehrer; Lisa Miorin; Elena Moreno; Arvind H. Patel; Suzannah Rihn; Mir M. Khalid; Albert Vallejo-Gracia; Parinaz Fozouni; Camille R. Simoneau; Theodore L. Roth; David Wu; Mohd Anisul Karim; Maya Ghoussaini; Ian Dunham; Francesco Berardi; Sebastian Weigang; Maxime Chazal; Jisoo Park; James Logue; Marisa McGrath; Stuart Weston; Robert Haupt; C. James Hastie; Matthew Elliott; Fiona Brown; Kerry A. Burness; Elaine Reid; Mark Dorward; Clare Johnson; Stuart G. Wilkinson; Anna Geyer; Daniel M. Giesel; Carla Baillie; Samantha Raggett; Hannah Leech; Rachel Toth; Nicola Goodman; Kathleen C. Keough; Abigail L. Lind; Reyna J. Klesh; Kafi R. Hemphill; Jared Carlson-Stevermer; Jennifer Oki; Kevin Holden; Travis Maures; Katherine S. Pollard; Andrej Sali; David A. Agard; Yifan Cheng; James S. Fraser; Adam Frost; Natalia Jura; Tanja Kortemme; Aashish Manglik; Daniel R. Southworth; Robert M. Stroud; Dario R. Alessi; Paul Davies; Matthew B. Frieman; Trey Ideker; Carmen Abate; Nolwenn Jouvenet; Georg Kochs; Brian Shoichet; Melanie Ott; Massimo Palmarini; Kevan M. Shokat; Adolfo García-Sastre; Jeremy A. Rassen; Robert Grosse; Oren S. Rosenberg; Kliment A. Verba; Christopher F. Basler; Marco Vignuzzi; Andrew A. Peden; Pedro Beltrao; Nevan J. Krogan; Tristan W. Owens; Meghna Gupta; Sergei Pourmal; Erron W. Titus; Caleigh M. Azumaya; Christian Billesbølle; Axel F. Brilot; Melody G. Campbell; Amy Diallo; Miles Sasha Dickinson; Devan Diwanji; Nadia Herrera; Nick Hoppe; Huong T. Kratochvil; Yanxin Liu; Gregory E. Merz; Michelle Moritz; Henry C. Nguyen; Carlos Nowotny; Cristina Puchades; Alexandrea N. Rizo; Ursula Schulze-Gahmen; Amber M. Smith; Ming Sun; Iris D. Young; Jianhua Zhao; Daniel Asarnow; Justin Biel; Alisa Bowen; Julian R. Braxton; Jen Chen; Cynthia M. Chio; Un Seng Chio; Ishan Deshpande; Loan Doan; Bryan Faust; Sebastian Flores; Mingliang Jin; Kate Kim; Victor L. Lam; Fei Li; Junrui Li; Yen-Li Li; Yang Li; Xi Liu; Megan Lo; Kyle E. Lopez; Arthur A. Melo; Frank R. Moss; Phuong Nguyen; Joana Paulino; Komal Ishwar Pawar; Jessica K. Peters; Thomas H. Pospiech; Maliheh Safari; Smriti Sangwan; Kaitlin Schaefer; Paul V. Thomas; Aye C. Thwin; Raphael Trenker; Eric Tse; Tsz Kin Martin Tsui; Feng Wang; Natalie Whitis; Zanlin Yu; Kaihua Zhang; Yang Zhang; Fengbo Zhou; Donovan Trinidad; David A. Agard; Yifan Cheng; James S. Fraser; Adam Frost; Natalia Jura; Tanja Kortemme; Aashish Manglik; Daniel R. Southworth; Robert M. Stroud; Oren S. Rosenberg; Kliment A. Verba; Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Bodgan Kirilenko; Michael Hiller; Klaus-Peter Koepfli; Irene Kaplow; Morgan Wirthlin; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Abigail Lind; Katherine S. Pollard; Oliver A. Ryderq; Martin T. Nweeia; Jennifer Meadows; Michael Dong; Ola Wallerman; Vikki Marinescu; Kerstin Lindblad-Toh; David A. Ray; Sarahjane Power; Emma C. Teeling; Gaurav Chauhan; Shirley Xue Li; Elinor K. Karlsson; Harris A. Lewin; ;
<jats:title>How lethal coronaviruses engage hosts</jats:title> <jats:p> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordon <jats:italic>et al.</jats:italic> mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe9403">eabe9403</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Low-income students lose ground
Christopher Avery; Susan Dynarski; Sarah Turner
<jats:p>Income inequality in college attendance and graduation in the United States was troublingly large before the pandemic. Without an aggressive infusion of federal support for schools and students, these already sizable gaps will likely widen into chasms.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1141-1141
News at a glance
<jats:p>A roundup of weekly science policy and related news.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1142-1143
‘The game has changed.’ AI triumphs at protein folding
Robert F. Service
<jats:p>In milestone, software predictions finally match structures calculated from experimental data.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1144-1145
Why were salmon dying? The answer washed off the road
Erik Stokstad
<jats:p>Common tire chemical implicated in coho salmon kills.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1145-1145
Scientists fear no-deal Brexit as deadline looms
Cathleen O'Grady
<jats:p>U.K. researchers in limbo, weeks from crashing out of EU trade and travel rules.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1146-1146
How cats get their stripes and spots
Elizabeth Pennisi
<jats:p>Newly uncovered mechanism may pattern the coats of other mammals, too.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1147-1147
Federal hospital data system falters at tracking pandemic
Charles Piller
<jats:p>HHS Protect data, which influence how pandemic supplies and support are allocated, conflict with other data sources.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1148-1149
New challenges emerge for planned human challenge trials
Warren Cornwall
<jats:p>Scientists debate risks and benefits of intentionally exposing volunteers to dangerous virus.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1150-1150