Catálogo de publicaciones - revistas

<jats:p> Kang <jats:italic>et al</jats:italic> . (Reports, 19 June 2020, p. 1381) report a structure of the nitrogenase MoFe protein that is interpreted to indicate binding of N <jats:sub>2</jats:sub> or an N <jats:sub>2</jats:sub> -derived species to the active-site FeMo cofactor. Independent refinement of the structure and consideration of biochemical evidence do not support this claim. </jats:p>

<jats:title>Kinesin takes substeps</jats:title> <jats:p> Simultaneously measuring the nanoscale motion and forces that molecular machines generate provides insights into how they work mechanically to fulfill their cellular function. To study these machines, Sudhakar <jats:italic>et al.</jats:italic> developed germanium semiconductor nanospheres as probes for so-called optical tweezers. With these high–refractive index nanospheres, they improved the resolution of optical tweezers and discovered that the motor kinesin takes 4-nanometer substeps. Further, instead of detaching from their microtubule track under load, motors slid back on it, enabling rapid reengagement in transport. The new technology will allow investigation of a range of other proteins and their behaviors at nanometer scales. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd9944">eabd9944</jats:related-article> </jats:p>

<jats:title>Machine learning for medicine</jats:title> <jats:p> Small-molecule screens aimed at identifying therapeutic candidates traditionally search for molecules that affect one to several outputs at most, limiting discovery of true disease-modifying drugs. Theodoris <jats:italic>et al.</jats:italic> developed a machine-learning approach to identify small molecules that broadly correct gene networks dysregulated in a human induced pluripotent stem cell disease model of a common form of heart disease involving the aortic valve. Gene network correction by the most efficacious therapeutic candidate generalized to primary aortic valve cells derived from more than 20 patients with sporadic aortic valve disease and prevented aortic valve disease in vivo in a mouse model. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd0724">eabd0724</jats:related-article> </jats:p>

<jats:p> The <jats:italic>Science</jats:italic> family of journals is launching a number of new initiatives related to our editorial policies. We now have a web page listing several important metrics for scientific journals ( <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/journal-metrics">www.sciencemag.org/journal-metrics</jats:ext-link> ). This information will be updated at the end of each year with new data. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Some experts say Biden administration plan is too modest to track fast-evolving variants as they arise and spread.</jats:p>

<jats:p>Hidden genetic pathways behind land-water transition are found in living fish.</jats:p>

<jats:p>New evidence highlights need for policy changes to aid female scientists.</jats:p>

<jats:p>Landmark analysis of 7000 Chicago police shows nonwhite and female officers make fewer stops.</jats:p>

<jats:p>Editors differ about whether they are obliged to ensure specimens are legally acquired.</jats:p>