Catálogo de publicaciones - revistas

<jats:title>Regulating multiple body clocks</jats:title> <jats:p>Circadian rhythms that affect multiple tissues and organ systems are aligned with the dark-light cycle and other external inputs such as feeding. But how is such time keeping modulated throughout complex systems and anatomical regions? Koronowski and Sassone-Corsi reviewed how central regulators in the brain and peripheral regulators throughout organs can behave cooperatively or independently to modulate circadian rhythms. This systemic view of circadian rhythm modulation is important to understand behavior and disease, because dysregulated clocks are associated with metabolic syndrome and cancer.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd0951">eabd0951</jats:related-article> </jats:p>

<jats:title>Brain organoids with Neanderthal genes</jats:title> <jats:p> The genomes of Neanderthals and modern humans are overall very similar. To understand the impact of genetic variants that are specific to modern humans, Trujillo <jats:italic>et al.</jats:italic> performed a genome-wide analysis to identify 61 coding variants in protein-coding genes. Identifying the gene encoding the RNA-binding protein <jats:italic>NOVA1</jats:italic> as a top candidate for functional analyses, they introduced the archaic gene variant into human pluripotent stem cells and generated brain organoids. These organoids showed alterations in gene expression and splicing as well as morphology and synaptogenesis, suggesting that this method could be used to explore other genetic changes that underlie the phenotypic traits separating our species from extinct relatives. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax2537">eaax2537</jats:related-article> </jats:p>

<jats:p> Peters <jats:italic>et al</jats:italic> . comment on our report of the dynamic structure of the nitrogenase metallocofactor during N <jats:sub>2</jats:sub> reduction. Their claim that their independent structural refinement and consideration of biochemical data contradict our finding is incorrect and is strongly refuted by our biochemical and structural data that collectively and conclusively point to the binding of dinitrogen species to the nitrogenase cofactor. </jats:p>

<jats:title>A double punch against SARS-CoV-2</jats:title> <jats:p> Monoclonal antibodies are an important weapon in the battle against COVID-19. However, these large proteins are difficult to produce in the needed quantities and at low cost. Attention has turned to nanobodies, which are aptly named, single-domain antibodies that are easier to produce and have the potential to be administered by inhalation. Koenig <jats:italic>et al.</jats:italic> describe four nanobodies that bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent infection of cells (see the Perspective by Saelens and Schepens). Structures show that the nanobodies target two distinct epitopes on the SARS-CoV-2 spike protein. Multivalent nanobodies neutralize virus much more potently than single nanobodies, and multivalent nanobodies that bind two epitopes prevent the emergence of viral escape mutants. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe6230">eabe6230</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="681" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abg2294">681</jats:related-article> </jats:p>

<jats:title>The cells of songbird motor circuits</jats:title> <jats:p> Birds have complex motor and cognitive abilities that rival or exceed the performance of many mammals, but their brains are organized in a notably different way. Parts of the bird brain have been functionally compared to the mammalian neocortex. However, it is still controversial to what extent these regions are truly homologous with the neocortex or if instead they are examples of evolutionary convergence. Colquitt <jats:italic>et al.</jats:italic> used single-cell sequencing to identify and characterize the major classes of neurons that comprise the song-control system in birds (see the Perspective by Tosches). They found multiple previously unknown neural classes in the bird telencephalon and shed new light on the long-standing controversy regarding the nature of homology between avian and mammalian brains. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd9704">eabd9704</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6530" page="676" related-article-type="in-this-issue" vol="371" xlink:href="10.1126/science.abf9551">676</jats:related-article> </jats:p>