Catálogo de publicaciones - revistas

<jats:title>Laser-controlled receptor clustering</jats:title> <jats:p> A strategy that allows light-controlled local confinement of a heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptor may help to elucidate signal transduction mechanisms. Sánchez <jats:italic>et al.</jats:italic> developed just such an approach using a poly-L-lysine-graft-polyethylene glycol copolymer with a photoactivatable head. Laser light could locally activate a chelator that rapidly (within seconds) captured polyhistidine-tagged neuropeptide Y receptors. Such receptor confinement enhanced calcium signaling and increased spreading and cell motility in cultured human cells. The ability to control the location, size, and density of receptor clusters may help to elucidate receptor signaling mechanisms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb7657">eabb7657</jats:related-article> </jats:p>

<jats:title>Separating microbes and cancers</jats:title> <jats:p> The role of microorganisms in causing and sustaining cancers has been in dispute for centuries. Through the lens of gut- and tumor-associated microbes, Sepich-Poore <jats:italic>et al.</jats:italic> review our current understanding of the microbiota in cancer, building a “microbially conscious” framework. The authors argue that humans should be considered as a meta-organism, but how our microbiota influences cancer is still not well understood mechanistically. Nevertheless, advances in microbiome research are improving our understanding of immuno-oncology and driving new diagnostic and therapeutic approaches. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abc4552">eabc4552</jats:related-article> </jats:p>

<jats:title>An IFN-γ feedback loop</jats:title> <jats:p> Innate lymphoid cells (ILCs) play important roles in tissue homeostasis and host defense. Type 1 ILCs (ILC1s) produce interferon-γ (IFN-γ) and require the transcriptional master regulator T-bet. The pathways underlying how these cells develop and differentiate have remained poorly understood. Bai <jats:italic>et al.</jats:italic> found that the adult mouse liver contains a population of Lin–Sca-1 <jats:sup>+</jats:sup> Mac-1 <jats:sup>+</jats:sup> hematopoietic stem cells (LSM HSCs) that preferentially differentiate into tissue-resident liver ILC1s. They further show that IFN-γ produced by mature ILC1s promotes the expansion and differentiation of LSM HSCs into ILC1s but not natural killer cells. This work expands our understanding of extramedullary hematopoiesis and underscores the unique immune status of the liver. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba4177">eaba4177</jats:related-article> </jats:p>

<jats:p> Hamer <jats:italic>et al</jats:italic> . argue that the variable “ever versus never had a same-sex partner” does not capture the complexity of human sexuality. We agree and said so in our paper. But Hamer <jats:italic>et al</jats:italic> . neglect to mention that we also reported follow-up analyses showing substantial overlap of the genetic influences on our main variable and on more nuanced measures of sexual behavior, attraction, and identity. </jats:p>