Catálogo de publicaciones - revistas

<jats:title>Combatting noise on the platform</jats:title> <jats:p> The potential of quantum computers to solve problems that are intractable for classical computers has driven advances in hardware fabrication. In practice, the main challenge in realizing quantum computers is that general, many-particle quantum states are highly sensitive to noise, which inevitably causes errors in quantum algorithms. Some noise sources are inherent to the current materials platforms. de Leon <jats:italic>et al.</jats:italic> review some of the materials challenges for five platforms for quantum computers and propose directions for their solution. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb2823">eabb2823</jats:related-article> </jats:p>

<jats:title>Recording many neurons for a long time</jats:title> <jats:p> The ultimate aim of chronic recordings is to sample from the same neuron over days and weeks. However, this goal has been difficult to achieve for large populations of neurons. Steinmetz <jats:italic>et al.</jats:italic> describe the development and testing of Neuropixels 2.0. This new electrophysiological recording tool is a miniaturized, high-density probe for both acute and long-term experiments combined with sophisticated software algorithms for fully automatic post hoc computational stabilization. The technique also provides a strategy for extending the number of recorded sites beyond the number of available recording channels. In freely moving animals, extremely large numbers of individual neurons could thus be followed and tracked with the same probe for weeks and occasionally months. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abf4588">eabf4588</jats:related-article> </jats:p>

<jats:title>Goblet cell diversity</jats:title> <jats:p> An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nyström <jats:italic>et al.</jats:italic> discovered that goblet cells are not all the same along the length of the gut; rather, they form different functional populations depending on location. Small-intestine mucus is laced with antimicrobial peptides and is permeable to small molecules; downstream, thicker mucus is generated that excludes bacteria and xenobiotics. Mucus oozes in thick plumes from goblet cells within the crypts to shield the stem cell niche. Between the crypts lie highly differentiated goblet cells producing permeable mucus. Together, both types of mucus form a network that shelters the gut epithelium. If, however, the intercrypt goblet cells become dysfunctional, the exposed epithelium is exposed to bacteria and vulnerable to developing colitis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb1590">eabb1590</jats:related-article> </jats:p>

<jats:p> Ness-Cohn <jats:italic>et al</jats:italic> . claim that our observations of transcriptional circadian rhythms in the absence of the core clock gene <jats:italic>Bmal1</jats:italic> in mouse skin fibroblast cells are supported by inadequate evidence. They claim that they were unable to reproduce some of the original findings with their reanalysis. We disagree with their analyses and outlook. </jats:p>

<jats:p> Ray <jats:italic>et al</jats:italic> . (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in <jats:italic>Bmal1</jats:italic> <jats:sup>–/–</jats:sup> liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses. </jats:p>

<jats:p>COVID-19 will be remembered for many things, including the pandemic that changed science communication. Much of the effect was positive. Outstanding epidemiologists, virologists, and public health experts became household names as they talked about the pandemic through mainstream media and social platforms. In the rapidly evolving situation, hearing directly from the scientific community was more important than ever. But former president Donald Trump and former vice president Mike Pence did enormous damage in the United States by appointing themselves scientists, logisticians, and chief economists and taking control of the information flow. The vaccine arrived, despite all the bungling, but in the meantime, many lives could have been saved had messages about dangers, challenges, and solutions come through more clearly. We still seem to be learning. Although the Biden administration appears to have a firmer grip on the crisis, it now faces a new surge of infections brought on by the variants and an increase in the number of states loosening restrictions. How can science be better communicated in the future, given what we have seen during the pandemic?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Rare symptoms seen in AstraZeneca recipients occur after Johnson &amp; Johnson shot as well.</jats:p>

<jats:p>White House floats three new ARPA-like research offices in 2022 spending request to Congress.</jats:p>

<jats:p>First nuclear DNA from sediment shows turnover, migration among ancient cave dwellers in Spain.</jats:p>