Catálogo de publicaciones - revistas

<jats:title>Patterns and bottlenecks</jats:title> <jats:p> A year into the severe acute respiratory syndrome coronavirus 2 pandemic, we are experiencing waves of new variants emerging. Some of these variants have worrying functional implications, such as increased transmissibility or antibody treatment escape. Lythgoe <jats:italic>et al.</jats:italic> have undertaken in-depth sequencing of more than 1000 hospital patients' isolates to find out how the virus is mutating within individuals. Overall, there seem to be consistent and reproducible patterns of within-host virus diversity. The authors observed only one or two variants in most samples, but a few carried many variants. Although the evidence indicates strong purifying selection, including in the spike protein responsible for viral entry, the authors also saw evidence for transmission clusters associated with households and other possible superspreader events. After transmission, most variants fizzled out, but occasionally some initiated ongoing transmission and wider dissemination. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abg0821">eabg0821</jats:related-article> </jats:p>

<jats:p> Abruzzi <jats:italic>et al</jats:italic> . argue that transcriptome oscillations found in our study in the absence of <jats:italic>Bmal1</jats:italic> are of low amplitude, statistical significance, and consistency. However, their conclusions rely solely on a different statistical algorithm than we used. We provide statistical measures and additional analyses showing that our original analyses and observations are accurate. Further, we highlight independent lines of evidence indicating <jats:italic>Bmal1</jats:italic> -independent 24-hour molecular oscillations. </jats:p>

<jats:p> Ray <jats:italic>et al</jats:italic> . (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of <jats:italic>Bmal1</jats:italic> . </jats:p>

<jats:title>More is not always better</jats:title> <jats:p> Mutations in X-linked genes usually affect male individuals more than females, but the opposite characterizes the <jats:italic>Protocadherin-19</jats:italic> gene ( <jats:italic>PCDH19</jats:italic> ) on the X chromosome. Mutations in the PCDH19 cell-adhesion molecule cause cognitive impairment, affecting females more than males. Hoshina <jats:italic>et al.</jats:italic> studied mice with <jats:italic>PCDH19</jats:italic> mutations, showing that a mismatch between PCDH19 and another cell-adhesion molecule causes trouble when mossy fibers of the brain are forming synapses (see the Perspective by Shohayeb and Cooper). In the heterozygous setting, mutant PCDG19 sequesters the partner cell-adhesion molecule into dysfunctional complexes. In the hemizygous setting, as in males, enough of that partner cell-adhesion molecule roams free to make functional interactions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaz3893">eaaz3893</jats:related-article> ; see also p. <jats:related-article issue="6539" page="235" related-article-type="in-this-issue" vol="372">235</jats:related-article> </jats:p>

<jats:title>Mining wild animal microbiomes</jats:title> <jats:p> We have only just begun to examine the multitude of bacteria associated with other organisms. Levin <jats:italic>et al.</jats:italic> sampled the feces of 184 wild animals, including fish, birds, and mammals, from four different continents to survey the diversity of gut bacteria (see the Perspective by Lind and Pollard). They discovered more than 1000 previously undescribed bacterial species and identified factors that correlate with the composition, diversity, and functional content of the microbiota. Supporting the association of specific bacteria with animal lifestyle, they identified proteases, some previously undescribed, from the gut of griffon vultures that can break down toxins that may be present in their carrion diet. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abb5352">eabb5352</jats:related-article> ; see also p. <jats:related-article issue="6539" page="238" related-article-type="in-this-issue" vol="372">238</jats:related-article> </jats:p>