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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
Raoul De Gasparo; Mattia Pedotti; Luca Simonelli; Petr Nickl
; Frauke Muecksch; Irene Cassaniti; Elena Percivalle; Julio C. C. Lorenzi; Federica Mazzola; Davide Magrì; Tereza Michalcikova; Jan Haviernik; Vaclav Honig; Blanka Mrazkova; Natalie Polakova; Andrea Fortova; Jolana Tureckova; Veronika Iatsiuk; Salvatore Di Girolamo; Martin Palus; Dagmar Zudova; Petr Bednar; Ivana Bukova; Filippo Bianchini; Dora Mehn; Radim Nencka; Petra Strakova; Oto Pavlis; Jan Rozman; Sabrina Gioria; Josè Camilla Sammartino; Federica Giardina; Stefano Gaiarsa; Qiang Pan-Hammarström; Christopher O. Barnes; Pamela J. Bjorkman; Luigi Calzolai; Antonio Piralla; Fausto Baldanti; Michel C. Nussenzweig; Paul D. Bieniasz; Theodora Hatziioannou; Jan Prochazka; Radislav Sedlacek; Davide F. Robbiani; Daniel Ruzek; Luca Varani
Palabras clave: Multidisciplinary.
Pp. 424-428
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Kiran Musunuru; Alexandra C. Chadwick; Taiji Mizoguchi; Sara P. Garcia; Jamie E. DeNizio; Caroline W. Reiss; Kui Wang; Sowmya Iyer; Chaitali Dutta; Victoria Clendaniel; Michael Amaonye; Aaron Beach; Kathleen Berth; Souvik Biswas; Maurine C. Braun; Huei-Mei Chen; Thomas V. Colace; John D. Ganey; Soumyashree A. Gangopadhyay; Ryan Garrity; Lisa N. Kasiewicz; Jennifer Lavoie; James A. Madsen; Yuri Matsumoto; Anne Marie Mazzola; Yusuf S. Nasrullah; Joseph Nneji; Huilan Ren; Athul Sanjeev; Madeleine Shay; Mary R. Stahley; Steven H. Y. Fan; Ying K. Tam; Nicole M. Gaudelli; Giuseppe Ciaramella; Leslie E. Stolz; Padma Malyala; Christopher J. Cheng; Kallanthottathil G. Rajeev; Ellen Rohde; Andrew M. Bellinger; Sekar Kathiresan
Palabras clave: Multidisciplinary.
Pp. 429-434
Distinct fission signatures predict mitochondrial degradation or biogenesis
Tatjana Kleele; Timo Rey; Julius Winter; Sofia Zaganelli; Dora Mahecic; Hélène Perreten Lambert; Francesco Paolo Ruberto; Mohamed Nemir; Timothy Wai; Thierry Pedrazzini; Suliana Manley
Palabras clave: Multidisciplinary.
Pp. 435-439
Neuronal enhancers are hotspots for DNA single-strand break repair
Wei Wu; Sarah E. Hill; William J. Nathan; Jacob Paiano; Elsa Callen; Dongpeng Wang; Kenta Shinoda; Niek van Wietmarschen; Jennifer M. Colón-Mercado; Dali Zong; Raffaella De Pace; Han-Yu Shih; Steve Coon; Maia Parsadanian; Raphael Pavani; Hana Hanzlikova; Solji Park; Seol Kyoung Jung; Peter J. McHugh; Andres Canela; Chongyi Chen; Rafael Casellas; Keith W. Caldecott; Michael E. Ward; André Nussenzweig
Palabras clave: Multidisciplinary.
Pp. 440-444
Structure and dynamics of a mycobacterial type VII secretion system
Catalin M. Bunduc; Dirk Fahrenkamp; Jiri Wald; Roy Ummels; Wilbert Bitter; Edith N. G. Houben; Thomas C. Marlovits
<jats:title>Abstract</jats:title><jats:p><jats:italic>Mycobacterium tuberculosis</jats:italic> is the cause of one of the most important infectious diseases in humans, which leads to 1.4 million deaths every year<jats:sup>1</jats:sup>. Specialized protein transport systems—known as type VII secretion systems (T7SSs)—are central to the virulence of this pathogen, and are also crucial for nutrient and metabolite transport across the mycobacterial cell envelope<jats:sup>2,3</jats:sup>. Here we present the structure of an intact T7SS inner-membrane complex of <jats:italic>M. tuberculosis</jats:italic>. We show how the 2.32-MDa ESX-5 assembly, which contains 165 transmembrane helices, is restructured and stabilized as a trimer of dimers by the MycP<jats:sub>5</jats:sub> protease. A trimer of MycP<jats:sub>5</jats:sub> caps a central periplasmic dome-like chamber that is formed by three EccB<jats:sub>5</jats:sub> dimers, with the proteolytic sites of MycP<jats:sub>5</jats:sub> facing towards the cavity. This chamber suggests a central secretion and processing conduit. Complexes without MycP<jats:sub>5</jats:sub> show disruption of the EccB<jats:sub>5</jats:sub> periplasmic assembly and increased flexibility, which highlights the importance of MycP<jats:sub>5</jats:sub> for complex integrity. Beneath the EccB<jats:sub>5</jats:sub>–MycP<jats:sub>5</jats:sub> chamber, dimers of the EccC<jats:sub>5</jats:sub> ATPase assemble into three bundles of four transmembrane helices each, which together seal the potential central secretion channel. Individual cytoplasmic EccC<jats:sub>5</jats:sub> domains adopt two distinctive conformations that probably reflect different secretion states. Our work suggests a previously undescribed mechanism of protein transport and provides a structural scaffold to aid in the development of drugs against this major human pathogen.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 445-448
Structure of human telomerase holoenzyme with bound telomeric DNA
George E. Ghanim; Adam J. Fountain; Anne-Marie M. van Roon; Ramya Rangan; Rhiju Das; Kathleen Collins; Thi Hoang Duong Nguyen
Palabras clave: Multidisciplinary.
Pp. 449-453
Structures of telomerase at several steps of telomere repeat synthesis
Yao He; Yaqiang Wang; Baocheng Liu; Christina Helmling; Lukas Sušac; Ryan Cheng; Z. Hong Zhou; Juli Feigon
Palabras clave: Multidisciplinary.
Pp. 454-459
A lysine–cysteine redox switch with an NOS bridge regulates enzyme function
Marie Wensien; Fabian Rabe von Pappenheim; Lisa-Marie Funk; Patrick Kloskowski; Ute Curth; Ulf Diederichsen; Jon Uranga; Jin Ye; Pan Fang; Kuan-Ting Pan; Henning Urlaub; Ricardo A. Mata; Viktor Sautner; Kai Tittmann
Palabras clave: Multidisciplinary.
Pp. 460-464
University of Cape Town’s battle to tackle a racist legacy
Linda Nordling
Palabras clave: Multidisciplinary.
Pp. 465-467
Designing nano-sized chemotherapy
Virginia Gewin
Palabras clave: Multidisciplinary.
Pp. 470-470