Catálogo de publicaciones - revistas

<jats:p> Sabo <jats:italic>et al</jats:italic> . (Research Articles, 8 December 2017, p. 1270) used statistical relationships between flow and catch in a major Lower Mekong Basin fishery to propose a flow regime that they claim would increase catch, if implemented by proposed dams. However, their catch data were not adjusted for known variation in monitoring effort, invalidating their analysis. </jats:p>

<jats:title>Fossil Fagaceae from Patagonia</jats:title> <jats:p> The oak family Fagaceae is thought to have its evolutionary origins in northern temperate forests and Southeast Asia. Wilf <jats:italic>et al.</jats:italic> now report 52-million-year-old fossils from the Southern Hemisphere belonging to the still-living genus <jats:italic>Castanopsis</jats:italic> . Hypotheses of Fagaceae origins have focused only on the Northern Hemisphere. Ancestral <jats:italic>Castanopsis</jats:italic> may represent one of numerous paleo-Antarctic plant genera that are found with <jats:italic>Castanopsis</jats:italic> today in Southeast Asian rainforests. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw5139">eaaw5139</jats:related-article> </jats:p>

<jats:p> Williams <jats:italic>et al</jats:italic> . claim that the data used in Sabo <jats:italic>et al</jats:italic> . were improperly scaled to account for fishing effort, thereby invalidating the analysis. Here, we reanalyze the data rescaled per Williams <jats:italic>et al</jats:italic> . and following the methods in Sabo <jats:italic>et al</jats:italic> . Our original conclusions are robust to rescaling, thereby invalidating the assertion that our original analysis is invalid. </jats:p>

<jats:title>Somatic mosaicism in normal tissues</jats:title> <jats:p> Somatic cells can accumulate mutations over the course of an individual's lifetime. This generates cells that differ genetically at specific loci within the genome. To explore how this genetic diversity in individuals contributes to disease, Yizhak <jats:italic>et al.</jats:italic> developed a method to detect mutations from RNA sequencing data (see the Perspective by Tomasetti). Applying this method to Cancer Genome Atlas samples and normal samples from the Genotype-Tissue Expression (GTEx) project generated a tissue-specific study of mutation accumulation. Somatic mutations were detected in nearly all individuals and across many normal human tissues in genomic regions called cancer hotspots and in genes that play a role in cancer. Interestingly, the skin, lung, and esophagus exhibited the most mutations, suggesting that the environment generates many human mutations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw0726">eaaw0726</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6444" page="938" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax5525">938</jats:related-article> </jats:p>

<jats:title>Binary decisions refine fate decisions</jats:title> <jats:p> Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov <jats:italic>et al.</jats:italic> analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aas9536">eaas9536</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6444" page="937" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax7917">937</jats:related-article> </jats:p>