Catálogo de publicaciones - revistas

<jats:title>Dissecting hyperactivation in AD</jats:title> <jats:p> Progressive accumulation of amyloid β (Aβ) in the brain is a defining feature of Alzheimer's disease (AD). At late stages of AD, pathological Aβ accumulations cause neurodegeneration and cell death. However, neuronal dysfunction, consisting of an excessively increased activity in a fraction of brain neurons, already occurs in early stages of the disease. Zott <jats:italic>et al.</jats:italic> explored the cellular basis of this hyperactivity in mouse models of AD (see the Perspective by Selkoe). Aβ-mediated hyperactivation was linked to a defect in synaptic transmission exclusively in active neurons, with the most-active neurons having the highest risk of hyperactivation. Aβ-containing brain extracts from human AD patients sustained this vicious cycle, underscoring the potential relevance of this pathological mechanism in humans. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="559" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay0198">559</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="540" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay5188">540</jats:related-article> </jats:p>

<jats:title>Pinpointing a single fast radio burst</jats:title> <jats:p> Fast radio bursts (FRBs) are flashes of radio emission from distant astronomical sources. Two FRBs are known to have repeated, but most last just a few milliseconds and are never seen again. Most telescopes that are sensitive to single FRBs have poor angular resolutions, so the FRB host galaxies remain unknown. Bannister <jats:italic>et al.</jats:italic> used a dedicated observing mode on a radio interferometer to detect and localize the nonrepeating FRB 180924, then followed up with optical telescope observations (see the Perspective by Petroff). They found that the FRB came from a medium-sized galaxy at a cosmological distance. Localizing FRBs will help determine their causes and allow them to be used as cosmological probes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="565" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw5903">565</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="546" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay4330">546</jats:related-article> </jats:p>

<jats:title>Entanglement goes large</jats:title> <jats:p> The success of quantum computing relies on the ability to entangle large-scale systems. Various platforms are being pursued, with architectures based on superconducting qubits and trapped atoms being the most advanced. By entangling up to 20 qubits, Omran <jats:italic>et al.</jats:italic> and Song <jats:italic>et al.</jats:italic> —working with Rydberg atom qubits and superconducting qubits, respectively—demonstrate how far these platforms have reached. The demonstrated controllable generation and detection of entanglement on such quantum systems is promising for the development of large-scale quantum processors. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="570" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax9743">570</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="574" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay0600">574</jats:related-article> </jats:p>

<jats:title>Entanglement goes large</jats:title> <jats:p> The success of quantum computing relies on the ability to entangle large-scale systems. Various platforms are being pursued, with architectures based on superconducting qubits and trapped atoms being the most advanced. By entangling up to 20 qubits, Omran <jats:italic>et al.</jats:italic> and Song <jats:italic>et al.</jats:italic> —working with Rydberg atom qubits and superconducting qubits, respectively—demonstrate how far these platforms have reached. The demonstrated controllable generation and detection of entanglement on such quantum systems is promising for the development of large-scale quantum processors. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="570" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax9743">570</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="574" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay0600">574</jats:related-article> </jats:p>

<jats:title>Ultrahigh energy density dielectric film</jats:title> <jats:p> Dielectrics help hold charge as capacitors and are fundamental energy storage components. Improving energy density and other properties may help these materials be more competitive with batteries for energy storage applications. Pan <jats:italic>et al.</jats:italic> introduced a specific type of nanodomain structure in a BiFeO <jats:sub>3</jats:sub> -BaTiO <jats:sub>3</jats:sub> -SrTiO <jats:sub>3</jats:sub> solid solution that dramatically increased the energy density. The nanodomains were organized so as to minimize energy loss during polarization switching. The enhancement in the dielectric properties suggests that the strategy may be useful for designing high-performance dielectrics. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="578" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw8109">578</jats:related-article> </jats:p>

<jats:title>Middle Stone Age humans in high-altitude Africa</jats:title> <jats:p> Recent archaeological research has produced evidence of the earliest human occupation of high-altitude habitats in the Andes and the Tibetan Plateau. Ossendorf <jats:italic>et al.</jats:italic> now present the oldest evidence of human settlement and adaptation to areas above 4000-meter elevation in Africa (see the Perspective by Aldenderfer). Their excavations at a rock shelter in the Bale Mountains of Ethiopia reveal obsidian artifacts and faunal remains, including abundant burnt bones, mostly of giant mole-rats. The findings reveal the environmental conditions and show how Late Pleistocene humans adapted to the harsh environments of these glaciated high-altitude African landscapes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="583" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw8942">583</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6453" page="541" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay2334">541</jats:related-article> </jats:p>