Catálogo de publicaciones - revistas

<jats:p>Szuwalski argues that varying age structure can affect surplus production and that recruitment is a better metric of productivity. We explain how our null model controlled for age structure and other processes as explanations for the temperature-production relationship. Surplus production includes growth, recruitment, and other processes and provides a more complete description of food production impacts than does recruitment alone.</jats:p>

<jats:p> Free <jats:italic>et al</jats:italic> . (Reports, 1 March 2019, p. 979) linked sea surface temperature (SST) to surplus production and estimated a 4% decline in maximum sustainable yield (MSY) since 1930. Changes in MSY are expected when fitting production models to age-structured data, so attributing observed changes to SST is problematic. Analyses of recruitment (a metric of productivity in the same database) showed increases in global productivity. </jats:p>

<jats:title>A nuclear sensor of viral DNA?</jats:title> <jats:p> A signaling pathway in eukaryotes known as cGAS–STING recognizes the presence of cytosolic DNA, which alerts the immune system to viral infection or cellular damage. However, the majority of DNA viruses direct their genomic DNA into nuclei, suggesting that nuclear-specific sensing is also needed. L. Wang <jats:italic>et al.</jats:italic> find that during herpes simplex virus–1 infection, heterogeneous nuclear ribonucleoprotein A2B1 forms a complex with viral DNA, homodimerizes, and is demethylated. These events result in translocation of the complex to the cytosol and activation of the immune system through type I interferon signaling. Additionally, the complex promotes <jats:italic>N</jats:italic> <jats:sup>6</jats:sup> -methyladenosine modification and translocation of cGAS–STING–related mRNAs after DNA virus infection, further amplifying the immune response. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav0758">eaav0758</jats:related-article> </jats:p>

<jats:title>Sharp-wave ripples in the hippocampus</jats:title> <jats:p> What are the brain mechanisms responsible for episodic memory retrieval? Norman <jats:italic>et al.</jats:italic> investigated epilepsy patients who had electrodes implanted in the hippocampus and a variety of cortical areas. Using a visual learning paradigm, they examined the temporal relationship between the incidence of hippocampal sharp-wave ripples and recall. Effective encoding of visual information was associated with higher incidence of ripples. Successful recall was preceded by an increased probability of ripples, which were also associated with transient reemergence of activation patterns in higher visual cortical areas. Hippocampal ripples may thus boost recollections during episodic memory retrieval. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax1030">eaax1030</jats:related-article> </jats:p>

<jats:title>Putting a price on the powerhouse</jats:title> <jats:p>Mitochondria—the so-called powerhouse of the cell—are derived from bacterial endosymbionts. This history provides opportunities and challenges for their host cells, particularly metazoans, including humans. Youle reviews the interplay between host and mitochondrial biology and highlights how mitochondrial ancestry has influenced innate immune responses. Keeping mitochondria both healthy and in check is key to organismal health and, when perturbed, leads to a variety of pathologies, including Parkinson's disease and inflammation.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw9855">eaaw9855</jats:related-article> </jats:p>

<jats:p>The United States is experiencing a public health epidemic of mass shootings and other forms of gun violence. A convenient response seems to be blaming mental illness; after all, “who in their right mind would do this?” This is utterly wrong. Mental illnesses, certainly severe mental illnesses, are not the major cause of mass shootings. It also is dangerously stigmatizing to people who suffer from these devastating disorders and can subject them to inappropriate restrictions. According to the National Council for Behavioral Health, the best estimates are that individuals with mental illnesses are responsible for less than 4% of all violent crimes in the United States, and less than a third of people who commit mass shootings are diagnosably mentally ill. Moreover, a large majority of individuals with mental illnesses are not at high risk for committing violent acts. Continuing to blame mental illness distracts from finding the real causes of mass shootings and addressing them directly.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Scientists find ways to count male chicks before they hatch.</jats:p>

<jats:p>Antibody preparations that cut the death rate dramatically will become available to all patients in Congo.</jats:p>