Catálogo de publicaciones - revistas

<jats:title>Efficient sampling of equilibrium states</jats:title> <jats:p> Molecular dynamics or Monte Carlo methods can be used to sample equilibrium states, but these methods become computationally expensive for complex systems, where the transition from one equilibrium state to another may only occur through rare events. Noé <jats:italic>et al.</jats:italic> used neural networks and deep learning to generate distributions of independent soft condensed-matter samples at equilibrium (see the Perspective by Tuckerman). Supervised training is used to construct invertible transformations between the coordinates of the complex system of interest and simple Gaussian coordinates of the same dimensionality. Thus, configurations can be sampled in this simpler coordinate system and then transformed back into the complex one using the correct statistical weighting. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw1147">eaaw1147</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6457" page="982" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay2568">982</jats:related-article> </jats:p>

<jats:title>Heterogeneity in genome organization</jats:title> <jats:p>How the genome is organized in the three-dimensional space of the cell nucleus influences the activity of gene expression. Finn and Misteli review features of genome architecture and cell- and allele-specific variability in spatial genome organization. They also connect stochasticity in gene transcription and variability in genome organization and discuss the functional consequences of genome variability at the cell and population levels in development and disease.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw9498">eaaw9498</jats:related-article> </jats:p>

<jats:title>Ancient human movements through Asia</jats:title> <jats:p> Ancient DNA has allowed us to begin tracing the history of human movements across the globe. Narasimhan <jats:italic>et al.</jats:italic> identify a complex pattern of human migrations and admixture events in South and Central Asia by performing genetic analysis of more than 500 people who lived over the past 8000 years (see the Perspective by Schaefer and Shapiro). They establish key phases in the population prehistory of Eurasia, including the spread of farming peoples from the Near East, with movements both westward and eastward. The people known as the Yamnaya in the Bronze Age also moved both westward and eastward from a focal area located north of the Black Sea. The overall patterns of genetic clines reflect similar and parallel patterns in South Asia and Europe. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat7487">eaat7487</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6457" page="981" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay3550">981</jats:related-article> </jats:p>

<jats:title>Double warhead does DNA damage</jats:title> <jats:p> Strains of the human gut bacterium <jats:italic>Escherichia coli</jats:italic> carrying the <jats:italic>clb</jats:italic> gene cluster produce a secondary metabolite dubbed colibactin and have been provocatively linked to colorectal cancer in some models. Colibactin has been difficult to isolate in full, but pieces of the structure have been worked out, including an electrophilic warhead. Xue <jats:italic>et al.</jats:italic> found that colibactin contains two conjoined warheads, which is consistent with its ability to alkylate and cross-link DNA. Chemical synthesis and comparison to cell coculture confirm the structure and properties of this unstable and potentially carcinogenic metabolite. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax2685">eaax2685</jats:related-article> </jats:p>