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<jats:p> The ability to test validity by replicating experiments and comparing results is a cornerstone of science. The events that followed publication of “Sustained virologic control in SIV <jats:sup>+</jats:sup> macaques after antiretroviral and α <jats:sub>4</jats:sub> β <jats:sub>7</jats:sub> antibody therapy” by Byrareddy <jats:italic>et al.</jats:italic> in <jats:italic>Science</jats:italic> in 2016 (hereafter Byrareddy) provide insights into some challenges associated with replication. Byrareddy reported striking efficacy of an approach for controlling simian immunodeficiency virus (SIV) in rhesus macaques in a sustained manner, a result of potential importance for treatment of human HIV disease. Three papers in this issue report attempts to replicate these results. The matters associated with Byrareddy and these studies provide a concrete framework for discussing our policies related to replication studies. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Stalled in Hawaii, giant telescope faces roadblocks at its backup site in the Canary Islands.</jats:p>

<jats:p>All immunized Filipino kids should be tested, some say.</jats:p>

<jats:p>Lightning, drought, and invasive pests tend to slay the largest trees.</jats:p>

<jats:p>Having solved stability problems, chemists think metal-organic frameworks are ready for a commercial ascent.</jats:p>

<jats:p>New task force triggered by concerns about China.</jats:p>

<jats:p>The Lacandon Maya resisted Spanish conquest for nearly 200 years. This summer, archaeologists went looking for their capital.</jats:p>