Catálogo de publicaciones - revistas

<jats:title>cGAS sensing of DNA: A comprehensive look</jats:title> <jats:p>The immune system uses the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) signaling pathway to detect the presence of intracellular DNA. This is beneficial because cytosolic DNA is often a sign of host damage or invasion by pathogens. However, inappropriate responses to self-DNA must be suppressed to prevent detrimental effects on the host. Ablasser and Chen review the latest advances uncovering how cGAS and STING control inflammatory responses and are themselves regulated. Special attention is paid to the role of cGAS in sterile inflammatory conditions as well as to the therapeutic potential of modulating this pathway.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat8657">eaat8657</jats:related-article> </jats:p>

<jats:title>Hooking into antigen transfer</jats:title> <jats:p> Segmented filamentous bacteria (SFB) are anaerobic, spore-forming, clostridia-like organisms that are important immune modulators in the mammalian gut. For some reason, SFB do not provoke inflammatory responses. Ladinsky <jats:italic>et al.</jats:italic> probed the mechanistic basis of this soothing effect in mice. SFB attach tightly to intestinal epithelial cells via a hook-like structure. Bacterial material is extruded from the hook and enters the host cell by endocytosis. An extruded SFB protein called P3340 is shuttled by the host protein cell division control protein 42 homolog (CDC42) through the endosomelysosome vesicular pathway to the basolateral side of the intestinal epithelial cell. Here, it prompts an immunomodulatory SFB-specific CD4 T helper 17 cell response, possibly via intestinal macrophages. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aat4042">eaat4042</jats:related-article> </jats:p>

<jats:title>Quickly exploring weakly coupled oscillators</jats:title> <jats:p> Synchronizing oscillators have been useful models for exploring coupling in dynamic systems. However, many macroscopic platforms such as pendula evolve on slow time scales, which can limit the observation of states that emerge after many cycles. Matheny <jats:italic>et al.</jats:italic> fabricated a ring of eight nanoelectromechanical oscillators resonating at ∼2.2 megahertz with quality factors of ∼4000 that could be rapidly controlled and read out. Analysis of these large datasets revealed exotic synchronization states with complex dynamics and broken symmetries. Theoretical modeling showed that emergent higher-order interactions (such as biharmonic and next-nearest neighbor) stabilized complex dynamics, despite the network having weak nearest-neighbor coupling. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav7932">eaav7932</jats:related-article> </jats:p>