Catálogo de publicaciones - revistas

<jats:title>A small molecule that targets influenza</jats:title> <jats:p> Many of us rely on seasonal vaccines for protection against influenza and are only too aware of their limited breadth. Broadly neutralizing antibodies (bnAbs) that target the conserved hemagglutinin (HA) stem of the influenza virus provide hope for the development of universal vaccines and are being evaluated in clinical trials. Van Dongen <jats:italic>et al.</jats:italic> selected and optimized a small-molecule lead compound that recapitulates key interactions of the bnAb with HA. Like the bnAb, the compound inhibited viral fusion in the endosomes of target cells. The compound protected mice from influenza after oral administration and neutralized virus infection in a 3D cell culture of human bronchial epithelial cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aar6221">eaar6221</jats:related-article> </jats:p>

<jats:p>Years of sociopolitical unrest in Nicaragua and Venezuela have given rise to a human rights and humanitarian crisis in Latin America. Last week, the situation in both countries took a serious turn. In Nicaragua, the government began negotiations with the opposition to end the political crisis, while continuing to repress and harass university students and independent media. In Venezuela, the escalating crisis resulted in the blocking and burning of humanitarian aid at the border—a development that was widely condemned by the rest of the world. Political instability and insecurity in both countries have had a disastrous economic impact on many sectors. The human resource base critical for meeting urgent and long-term needs in these societies is being devastated. As scientists who are members of academies that belong to the InterAmerican Network of Academies of Sciences, we are deeply troubled by these situations and call on the global scientific community to show solidarity with the academic communities in Nicaragua and Venezuela.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Letters singling out faculty who may not have disclosed links could chill collaborations.</jats:p>

<jats:p>Long-term disappearance of virus after a stem cell transplant may guide less drastic cures.</jats:p>

<jats:p>An interdisciplinary cadre of researchers suggests medieval plague transformed societies.</jats:p>

<jats:p>Move is response to CRISPR-altered babies.</jats:p>

<jats:p>University rejects Elsevier's journal subscriptions offer.</jats:p>

<jats:p>Protesters assail committee that recommends which vaccines Americans should receive.</jats:p>