Catálogo de publicaciones - revistas

<jats:title>An interacting topological phase</jats:title> <jats:p> Most topologically nontrivial systems discovered to date consist of noninteracting particles. Their properties can therefore be explained within a single-particle picture. De Léséleuc <jats:italic>et al.</jats:italic> engineered a topological phase of bosonic atoms in which interactions play a crucial role. The atoms, which were in highly excited Rydberg states, were held in an array of optical tweezers. Depending on the spatial arrangement of the tweezers, the dipole-dipole interactions between the atoms gave rise to two configurations with different topological properties. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="775" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aav9105">775</jats:related-article> </jats:p>

<jats:title>A CRISPR set of materials</jats:title> <jats:p> CRISPR technology is best known as a gene editing tool. English <jats:italic>et al.</jats:italic> developed a group of stimuli-responsive hydrogels to respond to the programmable nuclease Cas12a (see the Perspective by Han <jats:italic>et al.</jats:italic> ). The materials undergo molecular to macroscopic changes after Cas12a-dependent cleavage of double- or single-stranded DNA integrated into the gel. The authors show controlled release of particles linked to or imprisoned within the DNA, degradation of a gel with DNA solely forming the cross-links, and permeabilization of a gel with DNA partially forming the cross-links. These tools allow for the production of materials that release encapsulated nanoparticles and cells, act as degradable fuses, and enable remote radio-frequency identification signaling. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="780" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw5122">780</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="754" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay4198">754</jats:related-article> </jats:p>

<jats:title>Manifold destiny</jats:title> <jats:p> Mapping of genetic interactions (GIs) is usually based on cell fitness as the phenotypic readout, which obscures the mechanistic origin of interactions. Norman <jats:italic>et al.</jats:italic> developed a framework for mapping and understanding GIs. This approach leverages high-dimensional single-cell RNA sequencing data gathered from CRISPR-mediated, pooled perturbation screens. Diverse transcriptomic phenotypes construct a “manifold” representing all possible states of the cell. Each perturbation and GI projects the cell state to a particular position on this manifold, enabling unbiased ordering of genes in pathways and systematic classifications of GIs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="786" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax4438">786</jats:related-article> </jats:p>

<jats:title>NAD depletion as pathogen response</jats:title> <jats:p> One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield <jats:italic>et al.</jats:italic> and Wan <jats:italic>et al.</jats:italic> report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD <jats:sup>+</jats:sup> ) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD <jats:sup>+</jats:sup> depletion during Wallerian degeneration of neurons. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="793" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax1911">793</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="799" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax1771">799</jats:related-article> </jats:p>

<jats:title>NAD depletion as pathogen response</jats:title> <jats:p> One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield <jats:italic>et al.</jats:italic> and Wan <jats:italic>et al.</jats:italic> report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD <jats:sup>+</jats:sup> ) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD <jats:sup>+</jats:sup> depletion during Wallerian degeneration of neurons. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="793" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax1911">793</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="799" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax1771">799</jats:related-article> </jats:p>

<jats:title>Joining the laser welding club</jats:title> <jats:p> Laser welding is an integral part of modern manufacturing, but it fractures ceramic materials. Penilla <jats:italic>et al.</jats:italic> developed two methods for welding ceramics using ultrafast lasers. One method tunes the ceramic properties, allowing the laser to transit through the ceramic and weld at the interface between pieces. The other method optimizes a gap between pieces to efficiently deposit energy. Both methods leverage short but energetic pulses to create a melt pool that allows ceramics to be joined, without the high temperature used for traditional ceramic welds. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="803" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw6699">803</jats:related-article> </jats:p>

<jats:title>Slow earthquake segmentation</jats:title> <jats:p> The Japan Trench is responsible for disastrous megathrust earthquakes like the 2011 Tohoku-Oki quake. Nishikawa <jats:italic>et al.</jats:italic> used new observations from the S-net ocean-bottom seismic network to map slow earthquakes—disturbances that do not cause ground shaking—along the Japan Trench (see the Perspective by Houston). They found that the area that ruptured during the 2011 quake was bounded by areas that have large numbers of slow earthquakes. A segmentation likely caused the 2011 rupture to cease, an observation that is important for assessing risk from future major earthquakes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="808" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax5618">808</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="750" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay5621">750</jats:related-article> </jats:p>