Catálogo de publicaciones - revistas

<jats:title>Ebb and flow of parasite populations</jats:title> <jats:p> The population genetics of the malaria parasite <jats:italic>Plasmodium falciparum</jats:italic> across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power of genomics, Amambua-Ngwa <jats:italic>et al.</jats:italic> of the Plasmodium Diversity Network Africa found substantial population structure within Africa that is consistent with human and vector population divergence (see the Perspective by Sibley). Specific signatures of selection by antimalarial drugs were detected, along with indications of the effect of colonization and slavery. Furthermore, whole-genome sequencing showed that there is extensive gene flow among the different regions and that Ethiopia has a distinctive population of <jats:italic>P. falciparum</jats:italic> , which may be indicative of coexistence with another malaria parasite, <jats:italic>P. vivax.</jats:italic> </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="813" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aav5427">813</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="752" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay0988">752</jats:related-article> </jats:p>

<jats:title>Landing on the surface of Ryugu</jats:title> <jats:p> In October 2018, the Hayabusa2 spacecraft dropped the Mobile Asteroid Surface Scout (MASCOT) lander onto the surface of the asteroid (162173) Ryugu. Jaumann <jats:italic>et al.</jats:italic> analyzed images taken by the MASCOT camera during its descent and when resting on the surface. Colored light-emitting diodes were used to illuminate the lander's surroundings at night and produce color images. Ryugu's surface is dominated by two types of rock, but there is no evidence for fine-grained dust. Millimeter-sized inclusions in the rocks are similar to those present in carbonaceous chondrite meteorites. MASCOT operated for 17 hours on the surface before its nonrechargeable batteries ran out. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="817" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aaw8627">817</jats:related-article> </jats:p>

<jats:title>Robust memories through neuron networks</jats:title> <jats:p> How does the brain store information over a long period of time? Gonzalez <jats:italic>et al.</jats:italic> chronically implanted custom-built high-sensitivity microendoscopes and performed long-term imaging of neuronal activity in freely moving mutant mice. The majority of neurons were active on most days, but their firing rate changed across sessions and tasks. Although the responses of individual neurons changed, the responses of groups of neurons with synchronous activity were very stable across days and weeks. In addition, the network activity in hippocampal area CA1 recovered after an extended period without performing the task or even after abnormal activity induced by local lesions. These findings indicate the presence of attractor-like ensemble dynamics as a mechanism by which the representations of an environment are encoded in the brain. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="821" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aav9199">821</jats:related-article> </jats:p>

<jats:title>Keeping RNA processing contained</jats:title> <jats:p> Biomolecular condensates that assemble by phase separation are involved in RNA processing. Posttranslational modifications in intrinsically disordered regions of proteins can regulate RNA processing by regulating phase separation. Kim <jats:italic>et al.</jats:italic> used nuclear magnetic resonance spectroscopy to characterize phase separation in a model system comprising the C-terminal disordered regions of the translational regulators FMRP and CAPRIN1 that repress translation by deadenylating mRNA. Interactions between the proteins involve specific sequences in FMRP and CAPRIN1, and the propensity for mRNA to partition into the condensates depends on the phosphorylation patterns in the disordered regions. This mechanism integrates signaling pathways with the regulation of RNA processing. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6455" page="825" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aax4240">825</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>